Physical Sciences and Mathematics Commons^™

Development Of An Hplc-Based Oligosaccharide Synthesizer, Salvatore Pistorio

Dissertations

Carbohydrates are the most abundant molecules on Earth. They are involved in a wide range of fundamental biological processes: anti-inflammation, immune response, joint lubrication, cell growth, antigenic determination. Carbohydrates are also held responsible for many damaging cellular processes, such as bacterial and viral infections, development of tumors, etc.. Therefore, the development of effective methods for the synthesis of complex carbohydrates has become a critical area of glycosciences. One challenge that stands out is the stereocontrol in the synthesis of glycosidic bonds, the linkage that serves as the only means to connect simple monosaccharides into complex oligomeric networks. Beyond this, the …