Physical Sciences and Mathematics Commons^™

Stable Solution To L 2,1-Based Robust Inductive Matrix Completion And Its Application In Linking Long Noncoding Rnas To Human Diseases, Ashis Kumer Biswas, Dong-Chul Kim, Mingon Kang, Chris Ding, Jean X. Gao

Computer Science Faculty Publications and Presentations

Backgrounds

A large number of long intergenic non-coding RNAs (lincRNAs) are linked to a broad spectrum of human diseases. The disease association with many other lincRNAs still remain as puzzle. Validation of such links between the two entities through biological experiments are expensive. However, a plethora lincRNA-data are available now, thanks to the High Throughput Sequencing (HTS) platforms, Genome Wide Association Studies (GWAS), etc, which opens the opportunity for cutting-edge machine learning and data mining approaches to extract meaningful relationships among lincRNAs and diseases. However, there are only a few in silico lincRNA-disease association inference tools available to date, and …