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Terahertz Molecular Spectroscopy As A Tool For Analytical Probing Of Cellular Metabolism, Mitchell Cameron Paul
Terahertz Molecular Spectroscopy As A Tool For Analytical Probing Of Cellular Metabolism, Mitchell Cameron Paul
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Terahertz spectroscopy has found use as an analytical tool in determining chemical composition of exhaled human breath. This thesis demonstrates a novel application of this technology - analytical sensing of gaseous metabolic products of several types of human cell cultures. An innovative experimental system was developed for probing cellular metabolism using terahertz [THz] rotational spectroscopy. Gaseous emissions of cell cultures were analyzed and compared between several cell types. Cancerous and healthy lung cells as well as cancerous liver cells were studied. This technique carries a lot of promise as a noninvasive method of distinguishing between cell types and identifying cell …
Terahertz Molecular Spectroscopy As A Tool For Analytical Probing Of Cellular Metabolism, Mitchell Cameron Paul
Terahertz Molecular Spectroscopy As A Tool For Analytical Probing Of Cellular Metabolism, Mitchell Cameron Paul
Browse all Theses and Dissertations
Terahertz spectroscopy has found use as an analytical tool in determining chemical composition of exhaled human breath. This thesis demonstrates a novel application of this technology - analytical sensing of gaseous metabolic products of several types of human cell cultures. An innovative experimental system was developed for probing cellular metabolism using terahertz [THz] rotational spectroscopy. Gaseous emissions of cell cultures were analyzed and compared between several cell types. Cancerous and healthy lung cells as well as cancerous liver cells were studied. This technique carries a lot of promise as a noninvasive method of distinguishing between cell types and identifying cell …
Vespucci: A Free, Cross-Platform Software Tool For Spectroscopic Data Analysis And Imaging, Daniel Patrick Foose
Vespucci: A Free, Cross-Platform Software Tool For Spectroscopic Data Analysis And Imaging, Daniel Patrick Foose
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Vespucci is a software application developed for imaging and analysis of hyperspectral datasets. Vespucci offers several advantages over other software packages, including a simple user interface, no cost, and less restrictive licensing. Vespucci incorporates several analysis techniques including univariate imaging, principal components analysis, partial-least-squares regression, vertex components analysis and k- means clustering. Additionally, Vespucci can perform a number of useful data-processing operations, including filtering, normalization, baseline correction, and background subtraction. Datasets that consist of spatial or temporal data with a corresponding digital signal, including spectroscopic images, mass spectrometric images, and X-ray diffraction data can be processed in this software. The …
Terahertz Spectroscopic Breath Analysis As A Viable Analytical Chemical Sensing Technique, Robert M. Schueler
Terahertz Spectroscopic Breath Analysis As A Viable Analytical Chemical Sensing Technique, Robert M. Schueler
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The ability to quantify trace chemicals in human breath enables the possibility of identifying breath biomarkers to aid in diagnosis. The vast majority of the studies in the analytical breath analysis rely on GC-MS techniques for quantification of the human breath composition1,2,3,4. THz spectroscopy of breath is rapid, sensitive, and highly specific molecular identification in complex mixtures containing 10-100 analytes with near `absolute' specificity. THz spectroscopic breath analyzers require chemical preconcentration. A newly developed custom preconcentrator was constructed and compared in its performance to a commercial system. Unlike the commercial counterpart, the new system does not require cryogenic liquids, is …