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Full-Text Articles in Physical Sciences and Mathematics
Radiolabeled Nanohydroxyapatite As A Platform For The Development Of New Pet Imaging Agents, Stacy Lee Queern
Radiolabeled Nanohydroxyapatite As A Platform For The Development Of New Pet Imaging Agents, Stacy Lee Queern
Arts & Sciences Electronic Theses and Dissertations
Positron emission tomography (PET) imaging utilizes drugs labeled with positron emitters to target and evaluate different biological processes occurring in the body. Tailoring medicine to the individual allows for higher quality of care with better diagnosis and treatment and is a key purpose for advancing research into developing new platforms for PET imaging agents. A PET nuclide of high interest for the development of these agents is 89Zr. This can be attributed to the long half-life of 3.27 days and low positron energy of 89Zr.
In this work, we developed a production method for 89Zr using Y sputtered coins that …
Investigation Of 89zr-Siderophores As Molecular Imaging Agents For Positron Emission Tomography Imaging Of Bacterial Infections, Nora C. M. Goscinski
Investigation Of 89zr-Siderophores As Molecular Imaging Agents For Positron Emission Tomography Imaging Of Bacterial Infections, Nora C. M. Goscinski
Arts & Sciences Electronic Theses and Dissertations
Siderophores are small molecules synthesized by bacteria to harvest Fe3+ from their environment. In infection scenarios, their production can increase infection virulence by increasing the ability of bacteria to obtain Fe3+ and therefore grow more rapidly. The selective uptake of siderophores in vivo in multi-bacteria environments indicates that this class of molecules has a potential use as selective imaging agents. In this work, DFO-NCS and a library of trihydroxamate siderophores were evaluated as vehicles to deliver 89Zr selectively to bacteria for Positron Emission Tomography (PET) imaging of bacterial infections.
Productive work with radiometals involves thorough knowledge of …