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Full-Text Articles in Physical Sciences and Mathematics
Metabolomics Characterization Of U.S. And Japanese F-15 And C-130 Flight Line Crews Exposed To Jet Fuel Volatile Organic Compounds And Aerosols, Nicholas J. Delraso, David Mattie, Asao Kobayashi, Stephen W. Mitchell, Scott Dillard, Michael L. Raymer, Isaie Sibomana, Nicholas V. Reo
Metabolomics Characterization Of U.S. And Japanese F-15 And C-130 Flight Line Crews Exposed To Jet Fuel Volatile Organic Compounds And Aerosols, Nicholas J. Delraso, David Mattie, Asao Kobayashi, Stephen W. Mitchell, Scott Dillard, Michael L. Raymer, Isaie Sibomana, Nicholas V. Reo
Computer Science and Engineering Faculty Publications
Air and ground crews transfer a significant amount of jet fuel, and as a result of transfers, breathe its volatile emission from residues. Working on the flight line also exposes maintainers to exhaust from the jet fuel as engines are tested or run before and after flight. Since little is known concerning level of exposure and the corresponding biological response associated with human jet fuel exposure, nuclear magnetic resonance (NMR)-based metabolomics analysis of human urine was utilized for characterization of metabolite profiles of flight line personnel for potential biomarker discovery. This project was a collaborative research effort between the US …
Biomarkers Of Fatigue: Metabolomics Profiles Predictive Of Cognitive Performance, Nicholas J. Delraso, Deirdre A. Mahle, John J. Schlager, Donald L. Harville, Scott R. Chaiken, Danelle K. Roddy, Mari Chamberlain, Paul E. Anderson, Nicholas V. Reo, Michael L. Raymer, Isaie Sibomana
Biomarkers Of Fatigue: Metabolomics Profiles Predictive Of Cognitive Performance, Nicholas J. Delraso, Deirdre A. Mahle, John J. Schlager, Donald L. Harville, Scott R. Chaiken, Danelle K. Roddy, Mari Chamberlain, Paul E. Anderson, Nicholas V. Reo, Michael L. Raymer, Isaie Sibomana
Computer Science and Engineering Faculty Publications
Cognitive performance and fatigue are well known to be inversely related. Continuous and sustained actions in operational environments typically lead to reduced sleep normally required to perform optimally. These operational environments subject the warfighter to intense physical and mental exertion. Because fatigue continues to be an occupational hazard, leading to cognitive defects in performance, there has been a recognized need for real-time detection technologies that minimize fatigue-induced mishaps. I the current study, 23 subjects were subjected to 36h of sleep deprivation and cognitive psychomotor vigilance and automated neuropsychological assessment metric tests were conducted over the last 24 h of sleep …
Ontology Driven Semantic Provenance For Heterogeneous Bionomics Experimental Data, Satya S. Sahoo, Michael L. Raymer, Cory Andrew Henson, Amit P. Sheth, William S. York
Ontology Driven Semantic Provenance For Heterogeneous Bionomics Experimental Data, Satya S. Sahoo, Michael L. Raymer, Cory Andrew Henson, Amit P. Sheth, William S. York
Kno.e.sis Publications
Scientific experimental data generated by all the bionomic technologies is characterized by heterogeneity in its representation formats, constituents, and generation processes and, therefore, also in its usage. Using the proteomics domain we demonstrate the important role of provenance information o manage, interpret and analyze experimental data. We present a novel approach that employs an ontology as a knowledge model to automatically create semantic provenance information for high-throughput mass spectrometry (MS) data in the glycoproteomics domain. The Semantic Provenance Annotation of Data in protEomics (SPADE) implementation is based on the ProPreO ontology, a large-process ontology ( ~500 classes, 40 named relationships …