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Physical Sciences and Mathematics Commons™
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Full-Text Articles in Physical Sciences and Mathematics
Pharmaflights: Fragment Based Drug Discovery Based On Chalcones With A 3,4,5-Trimethoxy Substitution On Ring B., Cody Fourman
Pharmaflights: Fragment Based Drug Discovery Based On Chalcones With A 3,4,5-Trimethoxy Substitution On Ring B., Cody Fourman
The University Honors Program
The 3,4,5-trimethoxyphenyl motif is a common structural feature of a number of natural occurring antimitotic agents, especially those capable interacting with microtubules such as the cis-stilbene, combrestatin A-4. Chalcones possessing this pharmacophore have likewise been demonstrated to exhibit a diverse range of biological actions including anticancer, anti-invasive, antioxidant, and anti-inflammatory activities. As part of an experiential learning experience in academic drug discovery termed WSU PharmaFlights, so-called flights of 6-10 molecules based on a particular biologically relevant structural pattern on the privileged chalcone scaffold are to be designed, synthesized, and spectroscopically characterized as a starting point for lead-development with potential biological …
Chlorination Of 3-Arylsydnones With Iodine Monochloride, Ben Owens
Chlorination Of 3-Arylsydnones With Iodine Monochloride, Ben Owens
The University Honors Program
An improved method for the chlorination at the 4-position of 3- arylsydnones 1 was developed, using iodine monochloride (ICl) dissolved in DCM. 1,3,4-Oxadiazol-2(3H)-ones 3 were then synthesized from the resultant 4-chloro-3-arylsydnones 2. The scope and limitations will be presented.
Mosquito Hunter: An Intern's Perspective In A Public Health Department Mosquito Surveillance Program, Marisa Walterbusch
Mosquito Hunter: An Intern's Perspective In A Public Health Department Mosquito Surveillance Program, Marisa Walterbusch
The University Honors Program
As a Special Services Intern at Public Health - Dayton & Montgomery County (PHDMC), I gained first-hand experience as to the daily functioning of a Public Health Department and had the opportunity to work on a special project, the Mosquito Surveillance Program. PHDMC employs professionals in a variety of disciplines, all working towards the goal of protecting the health of the public. One way they accomplish this is through various inspections including restaurant, wellhead, and landfill. Another method to protect the public health is through the capture and testing of mosquitoes, with the goal of preventing the spread of mosquito-borne …
Investigating Problems With Mathematical Proof Skills, Samantha Collier
Investigating Problems With Mathematical Proof Skills, Samantha Collier
The University Honors Program
This research paper is focused on identifying and exploring problems that high school students have with the mathematical proof process. The study described in this report was designed to answer the question, do students who tend to struggle with mathematical proofs also struggle with understanding what is known and unknown in a proof, making assumptions about figures, and understanding mathematical converses? To answer these questions, students at three Dayton area high schools completed tasks relating to proofs and converse statements as well as a questionnaire. Contrary to the initial hypothesis, students who were perceived to have greater proof abilities did …