Physical Sciences and Mathematics Commons^™

Do Men Matter? In Statistics, Probably, Michael Kelly

WWU Honors College Senior Projects

In statistical genetics, there are several parameters of a dataset which a researcher might, but which are difficult to estimate in practice. In this paper, we will be focusing on allele frequencies, null alleles, inbreeding coefficients and, to a certain extent, beta values. A common technique for obtaining these values, developed by Amy Anderson and her co-workers, is to jointly estimate all of them using an EM-algorithm and the method of maximum likelihood. Despite this technique being effective in general, it is currently unable to deal with males at X-linked markers. The purpose of this project is to modify the …