Physical Sciences and Mathematics Commons^™

The Effects Of Solution Ph, Temperature And Redox Environment On Corrosion And Oxide Formation On Inconel X-750, Mohsen Bahrami

Electronic Thesis and Dissertation Repository

Nickel-based superalloys have a wide range of applications in different industries due to their exceptional mechanical and corrosion-resistance properties. These alloys are widely employed in the nuclear industry. Inside a nuclear reactor, these alloys are exposed to a continuous flux of gamma-radiation. When exposed to gamma-radiation, water decomposes, resulting in the production of oxidizing and reducing species. These species have a considerable effect on the redox chemistry of the solution, which controls the overall corrosion behaviour of nickel-based superalloys.

Corrosion of metals and alloys involves several elementary steps. A comprehensive understanding of these steps and how they influence each other …

Brown Dwarf Atmospheres At High Cadence And Spectral Resolution: A Speed Limit On Brown Dwarf Rotation And A Spectroscopic Atlas Of A 1050 K Atmosphere, Megan E. Tannock

Electronic Thesis and Dissertation Repository

Brown dwarfs are sub-stellar objects that form like stars but are not sufficiently massive to sustain hydrogen fusion in their cores. Characterized by cool, molecule-rich atmospheres, brown dwarfs demonstrate great diversity in spectroscopic appearance and share many properties with giant exoplanets. In this thesis I present two investigations: the first is a detailed photometric and spectroscopic study of the three most rapidly rotating brown dwarfs. The second examines a spectrum of a cool brown dwarf at unprecedented spectral resolution and signal-to-noise ratio to study the accuracy of theoretical model photospheres.

Photometric monitoring of brown dwarfs has revealed that periodic variability …

Lunar Regolith Simulant Behaviours Affected By Shock Metamorphism And Mineralogy, Xiao Chen Zhang

Electronic Thesis and Dissertation Repository

There are still many gaps in improving the fidelity of lunar regolith simulants to simulate more properties. This study compares some fundamental physical and mineralogical properties of three types of lunar highland regolith simulants: LHS-1, a commercial product with high mineralogical fidelity; UWO-1G, an original simulant that is the main component of LHS-1; and UWO-1S, another original product that is attempted to produce shocked grains in lunar simulants from pulverizing and mixing impact rocks sourced from the Mistastin Crater.

Preliminary results indicated that even though all simulants are composed of mostly plagioclase minerals and have similar particle size distribution patterns, …

Equisingular Approximation Of Analytic Germs, Aftab Yusuf Patel

Electronic Thesis and Dissertation Repository

This thesis deals with the problem of approximating germs of real or complex analytic spaces by Nash or algebraic germs. In particular, we investigate the problem of approximating analytic germs in various ways while preserving the Hilbert-Samuel function, which is of importance in the resolution of singularities. We first show that analytic germs that are complete intersections can be arbitrarily closely approximated by algebraic germs which are complete intersections with the same Hilbert-Samuel function. We then show that analytic germs whose local rings are Cohen-Macaulay can be arbitrarily closely approximated by Nash germs whose local rings are Cohen- Macaulay and …

A Computational Study On A Globular Protein And An Intrinsically Disordered Protein, Cecilia Chavez Garcia

Electronic Thesis and Dissertation Repository

We present molecular dynamics (MD) simulations of two protein targets for drug design: Triosephosphate isomerase (TIM) and Methyl CpG binding protein 2 (MeCP2). First, we studied three TIM proteins: TcTIM, TbTIM and a chimeric protein (Mut1). The first two are homologous enzymes with high sequence similarity, albeit different biophysical parameters. The chimeric protein has TbTIM’s sequence and 13 single point mutations, which are sufficient to obtain TcTIM-like behaviour in reactivation experiments. We analyzed the residue interaction networks observed in the all-atom MD simulations, as well as their electrostatic interactions and the impact of simulation length on them. A conserved salt …

Mechanism Of Thermal Protein Aggregation: Experiments And Molecular Dynamics Simulations On The High-Temperature Behavior Of Myoglobin., Yuen Ki Ng, Nastaran N Tajoddin, Pablo M Scrosati, Lars Konermann

Chemistry Publications

Proteins that encounter unfavorable solvent conditions are prone to aggregation, a phenomenon that remains poorly understood. This work focuses on myoglobin (Mb) as a model protein. Upon heating, Mb produces amorphous aggregates. Thermal unfolding experiments at low concentration (where aggregation is negligible), along with centrifugation assays, imply that Mb aggregation proceeds via globally unfolded conformers. This contrasts studies on other proteins that emphasized the role of partially folded structures as aggregate precursors. Molecular dynamics (MD) simulations were performed to gain insights into the mechanism by which heat-unfolded Mb molecules associate with one another. A prerequisite for these simulations was the …

Metal Release From A Biomedical Cocrmo Alloy In Mixed Protein Solutions Under Static And Sliding Conditions: Effects Of Protein Aggregation And Metal Precipitation, Zheng Wei, Valentine Romanovski, Luimar Filho, Cecilia Persson, Yolanda S. Hedberg

Chemistry Publications

Biomedical materials made of cobalt-chromium-molybdenum (CoCrMo) alloys are commonly used in artificial prostheses and dental implants, which are exposed to friction and load. The release of Co, Cr, and Mo from these surfaces is governed by physical and chemical processes. The extent of measured metal release from biomedical CoCrMo alloys into mixed protein solutions may be influenced by protein aggregation and metal precipitation effects. Metal release from, and the surface composition of, a CoCrMo alloy was investigated in physiological relevant solutions (phosphate buffered saline, PBS, with varying concentrations of fibrinogen from bovine plasma and/or bovine serum albumin) at pH 7.3 …

Machine Learning For Stock Prediction Based On Fundamental Analysis, Yuxuan Huang, Luiz Fernando Capretz, Danny Ho

Electrical and Computer Engineering Publications

Application of machine learning for stock prediction is attracting a lot of attention in recent years. A large amount of research has been conducted in this area and multiple existing results have shown that machine learning methods could be successfully used toward stock predicting using stocks’ historical data. Most of these existing approaches have focused on short term prediction using stocks’ historical price and technical indicators. In this paper, we prepared 22 years’ worth of stock quarterly financial data and investigated three machine learning algorithms: Feed-forward Neural Network (FNN), Random Forest (RF) and Adaptive Neural Fuzzy Inference System (ANFIS) for …

In Situ Study Of Geological Fluid Inclusions Using 23na Nuclear Magnetic Resonance Spectroscopy, Stephen Pilar

Electronic Thesis and Dissertation Repository

²³Na Magic Angle Spinning Solid State Nuclear Magnetic Resonance (MAS SS NMR) spectroscopy has been used to study natural geological samples of halite, fluorite, and quartz to evaluate the efficacy of NMR spectroscopy for in situ fluid inclusion analysis. NaCl calibration standards yielded a strong linear correlation (R²=0.9919) for salinity, albeit only over a ~1 ppm breadth of chemical shift. Fluid inclusions were successfully identified in all three types of minerals studied using MAS NMR. Chemical analysis with Inductively Coupled Plasma -- Mass Spectrometry (ICP-MS) was employed to quantify elemental contaminants in halite samples. Powder X-Ray Diffraction …

Metal Ligand Cooperative Complexes For Acceptorless Dehydrogenation Of Amines, Matthew D. Hoffman

Electronic Thesis and Dissertation Repository

Complexes of the type [M(Cp/Cp*)(MeCN)(P^R₂N^R′₂)]PF₆ (M = Fe, Ru) were synthesized and/or tested towards acceptorless dehydrogenation (AD) of amines. The primary amine benzylamine can undergo AD to form a mixture of products, and a selection of catalysts were employed in an attempt to control product selectivity. As a result, trends in product distribution were observed by modifying the primary and secondary coordination spheres on the catalyst. A new complex, [Fe(Cp)(MeCN)(P^Ph₂N^Ph₂)]PF₆ (3a) was synthesized and characterized and was found to be a completely selective dehydrogenation …

The Hashtag Project: The First Submillimeter Images Of The Andromeda Galaxy From The Ground, Matthew W.L. Smith, Stephen A. Eales, Thomas G. Williams, Bumhyun Lee, Zongnan Li, Pauline Barmby, Martin Bureau, Scott Chapman, Brian S. Cho, Aeree Chung, Eun Jung Chung, Hui Hsuan Chung, Christopher J.R. Clark, David L. Clements, Timothy A. Davis, Ilse De Looze, David J. Eden, Gayathri Athikkat-Eknath, George P. Ford, Yu Gao, Walter Gear, Haley L. Gomez, Richard De Grijs, Jinhua He, Luis C. Ho, Thomas M. Hughes, Sihan Jiao, Zhiyuan Li, Francisca Kemper

Physics and Astronomy Publications

Observing nearby galaxies with submillimeter telescopes on the ground has two major challenges. First, the brightness is significantly reduced at long submillimeter wavelengths compared to the brightness at the peak of the dust emission. Second, it is necessary to use a high-pass spatial filter to remove atmospheric noise on large angular scales, which has the unwelcome side effect of also removing the galaxy's large-scale structure. We have developed a technique for producing high-resolution submillimeter images of galaxies of large angular size by using the telescope on the ground to determine the small-scale structure (the large Fourier components) and a space …

Effects Of Gamma-Radiation On The Evolution Of Copper Corrosion Dynamics In Deep Geological Repository Solution Environments, Lindsay J. Grandy

Electronic Thesis and Dissertation Repository

The Canadian plan for permanent disposal of used nuclear fuel involves a used fuel container (UFC), a carbon steel vessel with a copper coating to provide the corrosion protection. The corrosion conditions for the copper layer of the UFC are expected to involve small, stagnant water volumes, pH values between 6 and 9, and a continuous flux of γ-radiation emitted from the radionuclides trapped in the fuel matrix. While γ-radiation does not affect the copper metal directly, humid air and water will radiolytically decompose into redox-active and acidic species which will be produced at constant concentrations and can alter the …

Characterization Of Ovarian Cancer-Derived Extracellular Vesicles By Surface-Enhanced Raman Spectroscopy., Nina M. Culum, Tyler T. Cooper, Gilles A. Lajoie, Thamara Dayarathna, Stephen H. Pasternak, Jiahui Liu, Yangxin Fu, Francois Lagugne-Labarthet, Lynne Marie Postovit

Chemistry Publications

Ovarian cancer is the most lethal gynecological malignancy, owing to the fact that most cases are diagnosed at a late stage. To improve prognosis and reduce mortality, we must develop methods for the early diagnosis of ovarian cancer. A step towards early and non-invasive cancer diagnosis is through the utilization of extracellular vesicles (EVs), which are nanoscale, membrane-bound vesicles that contain proteins and genetic material reflective of their parent cell. Thus, EVs secreted by cancer cells can be thought of as cancer biomarkers. In this paper, we present gold nanohole arrays for the capture of ovarian cancer (OvCa)-derived EVs and …

The Synthesis And Application Of Polyglyoxylamides, Quinton Ea Sirianni

Electronic Thesis and Dissertation Repository

Self-immolative polymers (SIPs) are a subset of degradable polymers that can be triggered to fully depolymerize with a single stimulus event. This amplifying behaviour makes them ideal for real-world applications including sensors, recyclable plastics, and drug delivery vehicles. Polyglyoxylates (PGs) are a class of SIPs that can be synthesized in a one-pot reaction and designed to respond to different stimuli including light, heat, reduction, and oxidation. However, with the exception of poly(ethyl glyoxylate) (PEtG), the various glyoxylate monomers must be prepared and purified before polymerization, which can be difficult. Furthermore, PGs typically possess properties such as water-insolubility and low glass …

Polyglyoxylamides With A Ph-Mediated Solubility And Depolymerization Switch, Quinton E. A. Sirianni, Xiaoli Liang, Georgina K. Such, Elizabeth Gillies

Chemistry Publications

Self-immolative polymers (SIPs) are characterized by their ability to depolymerize in response to the cleavage of a single end-cap or backbone moiety, making them attractive for numerous applications including sensors, transient plastics, and delivery vehicles. For many applications, it would be desirable to have an SIP capable of depolymerizing selectively under mildly acidic aqueous conditions. However, the poor solubility of most SIPs in water, accompanied by the competing effects of end-cap cleavage and depolymerization mechanisms, has made this a challenge. Here, we describe the development of polyglyoxylamides (PGAms) with pendent amino groups to achieve solubility switching at mildly acidic pH, …

Comparing The Popularity Of Testing Careers Among Canadian, Indian, Chinese, And Malaysian Students, Luiz Fernando Capretz, Pradeep Waychal, Jingdong Jia, Shuib Basri

Electrical and Computer Engineering Publications

This study attempts to understand motivators and de-motivators that influence the decisions of software students to take up and sustain software testing careers across four different countries, Canada, India, China, and Malaysia. Towards that end, we have developed a cross-sectional, but simple, survey-based instrument. In this study we investigated how software engineering and computer science students perceive and value what they do and their environmental settings. This study found that very few students are keen to take up software testing careers - why is this happening with such an important task in the software life cycle? The common advantages of …

Using Covalent Modifications To Distinguish Protein Electrospray Mechanisms: Charged Residue Model (Crm) Vs. Chain Ejection Model (Cem), Lars Konermann, Douglas J. D. Pimlott

Chemistry Publications

Different mechanisms have been proposed for the formation of gaseous protein ions during electrospray ionization (ESI). In the charged residue model (CRM) ions are produced upon nanodroplet evaporation to dryness. This mechanism is thought to dominate in native ESI, where proteins retain compact conformations, with charge states close to the Rayleigh charge of protein-sized aqueous droplets. Much higher charge states are generated from proteins that are unfolded in solution. The chain ejection model (CEM) has been proposed for ESI under such denaturing conditions. In the CEM proteins are gradually expelled, while mobile H⁺ equilibrate between the droplet and its …

Cache-Friendly, Modular And Parallel Schemes For Computing Subresultant Chains, Mohammadali Asadi

Electronic Thesis and Dissertation Repository

The RegularChains library in Maple offers a collection of commands for solving polynomial systems symbolically with taking advantage of the theory of regular chains. The primary goal of this thesis is algorithmic contributions, in particular, to high-performance computational schemes for subresultant chains and underlying routines to extend that of RegularChains in a C/C++ open-source library.

Subresultants are one of the most fundamental tools in computer algebra. They are at the core of numerous algorithms including, but not limited to, polynomial GCD computations, polynomial system solving, and symbolic integration. When the subresultant chain of two polynomials is involved in a client …

Structural Tuning And Spectroscopic Characterizations Of Polysulfide As Battery Materials, Daiqiang Liu

Electronic Thesis and Dissertation Repository

Polysulfide materials have drawn extensive attention for next-generation battery development since the current lithium-ion battery has almost reached its limit regarding energy density and safety issues. Many phosphorus and sodium sulfide materials have been used in different battery types, such as solid-state and sodium-sulfur batteries. However, there are still issues that prevent these techniques from applications. In recent years, there has been increasing attention on investigations of the structural and phase transformations of electrode and electrolyte materials under high pressure. Many studies have shown that external pressure can affect structural properties and influence electrical properties. In this study, three battery-related …

Hydrogen/Deuterium Exchange Measurements May Provide An Incomplete View Of Protein Dynamics: A Case Study On Cytochrome, Pablo M Scrosati, Victor Yin, Lars Konermann

Chemistry Publications

Many aspects of protein function rely on conformational fluctuations. Hydrogen/deuterium exchange (HDX) mass spectrometry (MS) provides a window into these dynamics. Despite the widespread use of HDX-MS, it remains unclear whether this technique provides a truly comprehensive view of protein dynamics. HDX is mediated by H-bond-opening/closing events, implying that HDX methods provide an H-bond-centric view. This raises the question if there could be fluctuations that leave the H-bond network unaffected, thereby rendering them undetectable by HDX-MS. We explore this issue in experiments on cytochrome

Post-Polymerization ‘Click’ End-Capping Of Polyglyoxylate Self-Immolative Polymers, Peter G. Maschmeyer, Xiaoli Liang, Allison Hung, Oksana Ahmadzai, Annmaree L. Kenny, Yuan C. Luong, Timothy N. Forder, Haoxiang Zeng, Elizabeth R. Gillies, Derrick A. Roberts

Chemistry Publications

No abstract provided.

Evolutionary Design Of Search And Triage Interfaces For Large Document Sets, Jonathan A. Demelo

Electronic Thesis and Dissertation Repository

This dissertation is concerned with the design of visual interfaces for searching and triaging large document sets. Data proliferation has generated new and challenging information-based tasks across various domains. Yet, as the document sets of these tasks grow, it has become increasingly difficult for users to remain active participants in the information-seeking process, such as when searching and triaging large document sets. During information search, users seek to understand their document set, align domain knowledge, formulate effective queries, and use those queries to develop document set mappings which help generate encounters with valued documents. During information triage, users encounter the …

Eveloping A Suitability Assessment Criteria For Software Developers: Behavioral Assessment Using Psychometric Test, Jayati Gulati, Bharti Suri, Luiz Fernando Capretz, Bimlesh Wadhwa, Anu Singh Lather

Electrical and Computer Engineering Publications

A suitability assessment instrument for software developers was created using a psychometric criteria that identify the impact of behavior on the performance of software engineers. The instrument uses a questionnaire to help both individuals and IT recruiters to identify the psychological factors that affect the working performance of software engineers. Our study identifies the relationship between the behavioral drivers and the programming abilities of the subjects. In order to evaluate the instrument, a total of 100 respondents were compared on the basis of their programming skills and nine behavioral drivers. It was concluded that there is a direct relationship between …

Self-Immolative Dendron Hydrogels, Karanpreet Gill, Xueli Mei, Elizabeth Gillies

Chemistry Publications

Smart hydrogels are of great interest in areas such as drug delivery and sensing. Dendrimer-based hydrogels can exhibit tunable properties due to their structural precision. We prepared hydrogels from self-immolative dendrons. Controlled hydrogel degradation in response to light was demonstrated and the hydrogel properties as a function of dendron generation were compared.

Compound Sums, Their Distributions, And Actuarial Pricing, Ang Li

Electronic Thesis and Dissertation Repository

Compound risk models are widely used in insurance companies to mathematically describe their aggregate amount of losses during certain time period. However, evaluation of the distribution of compound random variables and the computation of the relevant risk measures are non-trivial. Therefore, the main purpose of this thesis is to study the bounds and simulation methods for both univariate and multivariate compound distributions. The premium setting principles related to dependent multivariate compound distributions are studied. .

In the first part of this thesis, we consider the upper and lower bounds of the tail of bivariate compound distributions. Our results extend those …

Reconstructing Impact And Fluid Histories On Earth And Mars By Nanoscale Measurements, Gabriel A. Arcuri

Electronic Thesis and Dissertation Repository

The U-Pb geochronology minerals zircon (ZrSiO₄) and baddeleyite (ZrO₂) occur as microscopic grains in many planetary rocks, are among the oldest known solids, and preserve robust records of chemical, isotopic and orientation microstructures useful for reconstructing the evolution of early planetary lithospheres and hydrosphere. Less well known are the nanoscale characteristics of these long-lived minerals, and their connections, if any, to processes that operated at larger length scales in the crust important to habitability such as global planetary bombardment and fluid flow. The aim of this thesis was therefore to develop and apply nanoscale analytical techniques, …

Allostratigraphy Of The Lower Colorado Group (Cretaceous) In South-West Alberta, Slavena Galic

Electronic Thesis and Dissertation Repository

Clastic, upper Albian-lower Cenomanian strata were deposited in a low-accommodation backbulge depozone of the Western Canada Foreland Basin in SW Alberta. These strata are lithologically very heterogeneous and encompass a spectrum of depositional environments along an alluvial to offshore transect. These rocks are assigned, in subsurface, to the Lower Colorado Group, and in outcrop to the upper Blairmore Group. Lithological heterogeneity, as a result of rapid lateral facies changes, resulted in diverse nomenclature that obscured genetic relationships between time-equivalent strata. The present study integrates wireline log, core, and outcrop data to establish a high-resolution allostratigraphic framework which allowed recognition of …

Combined Geochemical, Mineralogical, And Structural Investigation Of Auriferous Quartz Veins At The Vertigo Target, White Gold District, West-Central Yukon Territory, Canada, James C M Alexander

Electronic Thesis and Dissertation Repository

The Vertigo target on the southwestern JP Ross property is a gold-mineralized showing ~70 km south of Dawson City in the White Gold district, west-central Yukon Territory, Canada. Favourable gold-mineralized zones occur with pathfinder elements As-Ag-Te-Pb-Bi. This study uses digital borehole logging, petrography, electron probe microanalysis, and micro-x-ray fluorescence to evaluate the spatial, geochemical, and mineralogical distribution of Au mineralization at the Vertigo target. Petrographic and structural interpretations are contextualized with synchrotron radiation x-ray diffraction on 120 drill sample pulps. The clustering of diffraction patterns has revealed characteristic signatures of Au-mineralization with structural geometries coincident with the mineralogical clusters. The …

Non-Circular Hydraulic Jumps Due To Inclined Jets, Ahmed Mohamed Abdelaziz

Electronic Thesis and Dissertation Repository

When a laminar inclined circular jet impinges on a horizontal surface, it forms a non-circular hydraulic jump governed by a non-axisymmetric flow. In this thesis, we use the boundary-layer and thin-film approaches in the three dimensions to theoretically analyse such flow and the hydraulic jumps produced in such cases. We particularly explore the interplay among inertia, gravity, and the effective inclination angle on the non-axisymmetric flow.

The boundary-layer height is found to show an azimuthal dependence at strong gravity level only; however, the thin film thickness as well as the hydraulic jump profile showed a strong non-axisymmetric behaviour at all …

Distribution Of The P-Torsion Of Jacobian Groups Of Regular Matroids, Sergio R. Zapata Ceballos

Electronic Thesis and Dissertation Repository

Given a regular matroid $M$ and a map $\lambda\colon E(M)\to \N$, we construct a regular matroid $M_\lambda$. Then we study the distribution of the $p$-torsion of the Jacobian groups of the family $\{M_\lambda\}_{\lambda\in\N^{E(M)}}$. We approach the problem by parameterizing the Jacobian groups of this family with non-trivial $p$-torsion by the $\F_p$-rational points of the configuration hypersurface associated to $M$. In this way, we reduce the problem to counting points over finite fields. As a result, we obtain a closed formula for the proportion of these groups with non-trivial $p$-torsion as well as some estimates. In addition, we show that the …