Physical Sciences and Mathematics Commons^™

Detecting Phenotype-Specific Interactions Between Biological Processes From Microarray Data And Annotations, Nadeem Ahmed Ansari

Wayne State University Dissertations

The development of high throughput technologies such as DNA microarrays has enabled researchers to measure expression levels on a genomic scale. Correct and efficient biological interpretation of the voluminous data generated by these technologies, however, remains a challenging problem. A commonly used approach in interpreting the results of such high throughput experiments is to map the list of differentially expressed (DE) genes to gene ontology (GO) terms, which provides a list of biological processes, biochemical functions, and cellular locations associated with the DE genes. A previously unexplored aspect is the identifications of unusual associations between biological processes. Such associations may …