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Oxidative Damage Caused By Iron Loading Into Ferritin, Talina Christensen Watts
Oxidative Damage Caused By Iron Loading Into Ferritin, Talina Christensen Watts
Undergraduate Honors Capstone Projects
Ferritin is the iron storage protein found in humans, animals, plants, fungi and bacteria. We are interested in how iron is loaded and stored in mammalian ferritin. Ferrous iron must be oxidized to ferric iron in order to be stored in ferritin. It is generally believed that ferritin does the loading itself, dependant upon a "ferroxidase activity." Oxidation of iron can result in the production of the hydroxyl radical which can cause oxidative damage to surrounding proteins and other biomolecules. An indicator of oxidative damage to proteins is the formation of carbonyl groups. Using only the H subunit of human …
Reduction Of N-Protected Amino Acids To Amino Alcohols And Subsequent Re-Oxidation To Original N-Protected Amino Acids, Val S. Goodfellow
Reduction Of N-Protected Amino Acids To Amino Alcohols And Subsequent Re-Oxidation To Original N-Protected Amino Acids, Val S. Goodfellow
Undergraduate Honors Capstone Projects
For the synthesis of certain molecules of interest in Dr. Richard Olsen's laboratory it was necessary to produce N-protected a-amino alcohols from N-protected amino acids and subsequently, after further synthesis steps, to oxidize the hydroxyl functionalities of these molecules back to carboxylic acids. A number of methods are known for the reduction of carboxylic acids to alcohols; several methods are also reported in the chemical literature for the oxidation of alcohols to carboxylic acids. The problem in finding a suitable general method, is that the amino acid side chains affect the re activity and chemistry differently in each specific case. …
Oxidation Of Thin Silver Films By Ozone And Atomic Oxygen, Lawrence R. Thorne
Oxidation Of Thin Silver Films By Ozone And Atomic Oxygen, Lawrence R. Thorne
Undergraduate Honors Capstone Projects
Recently, thin silver film detectors have been used to determine atomic oxygen profiles in the 70-100 km region of the upper atmosphere. The detectors' sensitivity to atomic oxygen is the result of the formation of silver oxide(s) which cause their electrical resistance to increase. A common procedure to calibrate and to make these detectors more sensitive is to cycle them through a series of three or more oxidations and reductions. This paper indicates that this cycling makes silver films more sensitive to ozone, causing them to be usable only at heights greater than 38 km. Also reported herein are experimentally …