Physical Sciences and Mathematics Commons^™

The Thermal Rearrangement Of Triarylacetonitrile Oxides., Leslie Wayne Gibbs

University of the Pacific Theses and Dissertations

This research is a detailed study of the rearrangement of triarylacetonitrile oxides to the corresponding triarylmethylisocyanates. The kinetics of the rearrangement of triphenylacetonitrlle oxide was followed by infrared absorption spectroscopy using the peak due to the N-0 stretching (1307cm^-1). A study, both, using the differential method (i.e., a plot of the logs of the initial slopes vs. the log of the concentration) and a check of the integrated forms of the rate expressions to determine which gave a constant value for the rate constant showed that the reaction is first order.

From measurements of the rate constant, k, …

Dipeptide Complexes Of Palladium(Ii) And Platinum(Ii), Lewis Enos Nance

University of the Pacific Theses and Dissertations

Due to recent interest in the role of heavy metals in enzymes. oxygen-carrying molecules. and anticarcinogenic compounds, the study of metal-protein bonding has assumed a new importance. Studies have been made utilizing platinum compounds as anticarcinogenic agents in several different types of cancerous activity. No study of the mechanism by which Pd(II) and Pt(II) compounds exhibit anticarcinogenic properties has been made to date.

The purpose of this research was to investigate the nature of bonding of Pd(II) and Pt(II) with various dipeptides, which were chosen in this study as a basic unit of protein-like material. These compounds have the advantage …

Birch Reduction Of Benzamide, N-Substituted Benzamides And Biphenylene, Luther Dickson

University of the Pacific Theses and Dissertations

The Birch reduction of benzamide with sodium and absolute ethanol. 95% ethanol, or tert-butanol in liquid ammonia gave 1,4-dihydrobenzamide in varying amounts. The amide group was not reduced. The two most important variables encountered were the alcohol used and whether or not ammonium chloride was added after the reduction was completed. Without this addition of ammonium chloride, little or no 1,4-dihydrobenzamide was present after workup, while with its addition some 1,4-dihydrobenzamide formed whether the proton source was absolute ethanol, 95% ethanol, or tert-butanol. The highest yield was obtained with tert-butanol with ammonium chloride being added. Addition of ammonium chloride apparently …

Perspectives In Hospital Pharmacy Design Based On Functional Requirements, Robert Kenneth Overend

University of the Pacific Theses and Dissertations

It is significant that the separation of pharmacy from medicine occurred for the first time in institutions under ecclesiastic authority which were devoted to the care of the sick. In this period of history, there was little division between the church and state; therefore, business did not play any part in the overall health care scheme. The prime consideration was the delivery of the highest quality of pharmaceutical and medical services. This was best accomplished by a division of labor between the expert in the medical treatment and the expert in the selection, preservation and prepagation of medicinals. In other …

A Study Of Selected Antineoplastic, Antibiotic, And Corticosteroid Drugs In Intravenous Admixtures, Melvin Philip Mcrae

University of the Pacific Theses and Dissertations

The benefits of intravenous therapy have become more and more apparent over the years. Medications can be given rapidly with an expectant rapid onset of action. The response to the drugs or fluids can often be closely controlled by regulating the dose or rate of administration. Frequently, adequate blood and tissue levels needed to eradicate many serious infections can be reached only by this route. Intravenous therapy is an especially appropriate method when the use of the oral tract, for one reason or another, cannot be used.

The development of intravenous therapy, however, did not proceed without its difficulties. Problems …

The Formulation And Physical Analyses Of Antibiotic Aerosol Foams For The Development Of Potential Topical Dermatologicals, Joseph Alexander Woelfel

University of the Pacific Theses and Dissertations

Within the last two decades the consumer market has been deluged with a diversity of aerosol products. The acceptability and utility of these products is reflected by the number found in the household and industry.

An antibiotic foam would obviate the necessity of manual application as is the case with the ointment or cream type products. Therefore, there would be less irritation to the already traumatized or infected sites by mechanical, chemical, or bacterial vectors.

Thus, the objective of this research will be to systematically develop suitable aerosol foam systems which contain therapeutically effective topical antibiotics with a subsequent evaluation …

Birch Reduction Of Benzenesulfonamide, N,N-Dimethylbenzenesulfonamide, N,N-Diisobutylbenzenesulfonamide, And 2-Mesitylenesulfonamide, Vishnubhai V. Patel

University of the Pacific Theses and Dissertations

It has been previously shown that benzenesulfonamide gives thiophenol and diphenyldisulfide upon Birch reduction. The sulfonamide group is easily reduced. Probably the electron deficient sulfur atom in sulfonamide can accommodate an electron easily.

The present study involved the Birch reduction of benzenesulfonamide, N,N-dimethylbenzenesulfonamide, N,N-diisobutylbenzenesulfonamide and 2-mesitylenesulfonamide.

The Identification Of Barbiturates By Attenuated Total Reflectance, Robert Lewis

University of the Pacific Theses and Dissertations

The use of Attenuated Total Reflectance as an analytical technique in infrared spectroscopy has become increasingly important in the past few years. ATR (Attenuated Total Reflectance) is a relatively new analytical method. Producing spectra of compounds by this method requires no solvent for dissolving the sample and no salts for making pellets. The only requirements for spectra production, similar in quality to those produced by conventional methods, are that there is enough sample to cover both sides of the reflector be similar. The index of the sample is fixed; therefore, the index of the reflector is controlled by selecting a …

Spectrophotometric And Microbiological Determination Of The Stability Of Sodium Ampicillin As Affected By Ph, Enrico Frank Raffanti

University of the Pacific Theses and Dissertations

The specific purpose of this investigation was to determine the effect of pH on the stability of ampicillin sodium for injection. Then, to correlate this information, a pH profile may be established to predict chemical stability with ampicillin sodium alone or when other drugs may be included in the admixture. With a pH profile the pharmacist could predict the length of time after which more than a 10 percent loss of activity would occur. Stability measurements were to be accomplished through a microbiological assay after adding ampicillin sodium to different buffer solutions. At the end of four hours, eight hours, …

Group Theoretic Properties Of Some Schröedinger Equations : Systematic Derivation, Sukeyuki Kumei

University of the Pacific Theses and Dissertations

In this thesis, I study the group theoretic structure of the Schrodinger equations of simple systems by making use of a new systematic method. Group theoretic analysis of Schrodinger equations have been made previously by numerous physicists. The groups found may be classified as: a) geometrical groups; b) dynamical degeneracy groups; c) dynamical groups

The geometrical group arises simply from the spatial symmetry of the system. Although the geometrical groups are very useful, they are not very interesting from the physical viewpoint.

On the other hand, the study of the dynamical degeneracy groups and the dynamical group is very attractive …

The Study Of The Isomerization Of Trans-3-Acetoxy-2-Bromocyclooctene, Virginia Hill Lewis

University of the Pacific Theses and Dissertations

The isomerization of trans-3-acetoxy-2-bromocyclooctene (trans-1) to cis-3-acetoxy-2-bromocyclooctene (cis-1) was studied, trans-3- Methoxy-2-bromocyclooctene (trans-2) was used as a model compound for comparison. The rate of isomerization of both compounds increased tremendously with iodine (free radical catalysis) and decresed tremendously in the presence of hydroquinone (free radical inhibitor). This showed that the isomerizations of trans-1 and trans-2 are free radical catalyzed. It was anticipated that acetoxyl participation in trans-1, by stabilizing the free radical intermediate, would cause the rate of rearrangement of trans-1 to be much greater than the rate of rearrangement of trans-2. However, trans-1 iscented only about four times faster …

Synthesis And Reactions Of Benzyl 2-Bromo-2-Deoxy Hexoses, Terry Cady Tompkins

University of the Pacific Theses and Dissertations

The purpose of this study is to show that the method just proposed can be used for the synthesis of 2-halo benzyl glycosides. And these derivatives can be used to synthesize biologically interesting compounds which were not previously attainable using the 2-halo-2-deoxy methyl glycosides which are currently available.

Birch Reduction Of Cinnamic Acid, John G. Little

University of the Pacific Theses and Dissertations

The use of alkali and alkaline earth metals as reducing agents in liquid ammonia solvent for aromatic and conjugated systems has been investigated by chemists at least since the early 1900's, e.g., Lebau and Picon (1). By subsequent additions of a proton source, the system yielded the first successful partial reduction of a monobenzenoid system, as reported by Wooster and Godfrey (2), in 1937. As a result of that success a patent was issued to Wooster for the process (3). Little additional work was reported until Birch and his co-workers picked up the investigation in the early 1940's. It was …