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Chitosan Adhesive Films For Photochemical Tissue Bonding, Antonio Lauto, Damia Mawad, Matthew Barton, Sabine C. Piller, Leonardo Longo

Australian Institute for Innovative Materials - Papers

Photochemical tissue bonding (PTB) is a promising sutureless technique for tissue repair. PTB is often achieved by applying a solution of rose bengal (RB) between two tissue edges, which are irradiated by a green laser to crosslink collagen fibers with minimal heat production. In this study, RB has been incorporated in chitosan films to create a novel tissue adhesive that is laser-activated. Materials and Methods. Adhesive films, based on chitosan and containing ∼0.1wt% RB were manufactured and bonded to calf intestine by a solid state laser (wavelength =532nm, Fluence ∼110J/cm2, spot size ∼5 mm). A single-column tensiometer, interfaced with a …