Physical Sciences and Mathematics Commons^™

Mathematical Modeling Of Microemulsification Processes, Numerical Simulations And Applications To Drug Delivery, Ogochukwu Nneka Ifeacho

Open Access Theses & Dissertations

Microemulsion systems are a great pharmaceutical tool for the delivery of formulations containing multiple hydrophilic and hydrophobic ingredients of varying physicochemical properties. These systems are gaining popularity because of its long shelf life, improved drug solubilisation capacity, easy preparation and improvement of bioavailability. Despite the advantages associated with the use of microemulsion systems in pharmaceutical industries, the major challenge impeding their use has been and continues to be the lack of understanding of these systems.

Microemulsions can be mathematically modeled by an initial boundary value problem involving a sixth order nonlinear time dependent equation. In this Thesis, we present a …

A Block Operator Splitting Method For Heterogeneous Multiscale Poroelasticity, Paul M. Delgado

Open Access Theses & Dissertations

Traditional models of poroelastic deformation in porous media assume relatively homogeneous material properties such that macroscopic constitutive relations lead to accurate results. Many realistic applications involve heterogeneous material properties whose oscillatory nature require multiscale methods to balance accuracy and efficiency in computation.

The current study develops a multiscale method for poroelastic deformation based on a fixed point iteration based operator splitting method and a heterogeneous multiscale method using finite volume and direct stiffness methods. To characterize the convergence

of the operator splitting method, we use a numerical root finding algorithm to determine a threshold surface in a non-dimensional parameter space …

Solving The Partial Differential Equation Of Vibrations With Interval Parameters Using The Interval Finite Difference Method, Brenda G. Medina

Open Access Theses & Dissertations

Accuracy and efficiency are among the main factors that drive today's innovative disciplines. As technology rapidly advances, efficiency takes on new meanings but what about accuracy? How accurate is accurate? Human error, uncertainties in measurement, and rounding errors are just some causes of inaccuracy. Interval Computations is an area that allows for such issues to be taken into account; for each measurement attained (for example), an interval can be built by considering the error associated with the measurement, and such an interval can be utilized in the mathematical computations of interest.

We consider the partial differential equation (PDE) of vibrations …