Physical Sciences and Mathematics Commons^™

Method Development For The Analysis Of Fatty Acids In Adipose Tissue Using Stir Bar Sorptive Extraction Coupled With Gas Chromatography-Mass Spectrometry, Angela Marisol Encerrado Manriquez

Open Access Theses & Dissertations

The project was aimed to develop an easy and sensitive analytical tool to study the role of fatty acids (FAs) profile in periprostatic adipose tissue (PPAT) and prostate cancer (PCa). PCa is the second leading cause of cancer-related death among American men. Although obesity has been mostly ruled out by many researchers as a risk factor for developing PCa, it has shown to be associated with PCa metastasis and progression. Periprostatic adipose tissue, which was present on 48% of prostatic surfaces, has been reported to act as energy sources for facilitating a positive microenvironment for PCa tumor progression. To understand …