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Stereoselectivity Of Phthalimido Β-Lactams Formation: Synthesis Of 3-Amino Β-Lactams Through A Facile Deprotection Reaction, Armando Paniagua, Ram Naresh Yadav, Sunena Chandra, Bimal K. Banik
Stereoselectivity Of Phthalimido Β-Lactams Formation: Synthesis Of 3-Amino Β-Lactams Through A Facile Deprotection Reaction, Armando Paniagua, Ram Naresh Yadav, Sunena Chandra, Bimal K. Banik
Chemistry Faculty Publications and Presentations
Synthesis of amino β-lactams is a crucial objective because of the medicinal properties associated with them and the products derived from of them. Stereocontrolled synthesis of phthalimido β-lactams is performed and cis and trans-phthalimido β-lactams are deprotected with ethylene diamine (and other reagents) to amino β-lactams of diverse structures in excellent yield. This reaction is also conducted under solventless conditions to afford identical products.