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Statistical Ensemble Analysis For Simulating Extrinsic Noise-Driven Response In Nf-Κb Signaling Networks, Jaewook Joo, Steven J. Plimpton, Jean-Loup Faulon

Physics and Astronomy Publications and Other Works

Background

Gene expression profiles and protein dynamics in single cells have a large cell-to-cell variability due to intracellular noise. Intracellular fluctuations originate from two sources: intrinsic noise due to the probabilistic nature of biochemical reactions and extrinsic noise due to randomized interactions of the cell with other cellular systems or its environment. Presently, there is no systematic parameterization and modeling scheme to simulate cellular response at the single cell level in the presence of extrinsic noise.

Results

In this paper, we propose a novel statistical ensemble method to simulate the distribution of heterogeneous cellular responses in single cells. We capture …