Physical Sciences and Mathematics Commons^™

Simple Mathematical Models Do Not Accurately Predict Early Siv Dynamics, Cecilia Noecker, Krista Schaefer, Kelly Zaccheo, Yiding Yang, Judy Day, Vitaly V. Ganusov

Faculty Publications and Other Works -- Mathematics

Upon infection of a new host, human immunodeficiency virus (HIV) replicates in the mucosal tissues and is generally undetectable in circulation for 1–2 weeks post-infection. Several interventions against HIV including vaccines and antiretroviral prophylaxis target virus replication at this earliest stage of infection. Mathematical models have been used to understand how HIV spreads from mucosal tissues systemically and what impact vaccination and/or antiretroviral prophylaxis has on viral eradication. Because predictions of such models have been rarely compared to experimental data, it remains unclear which processes included in these models are critical for predicting early HIV dynamics. Here we modified the …