Physical Sciences and Mathematics | Open Access Articles

Effects Of Fluoride On Submandibular Glands Of Mice: Changes In Oxidative Biochemistry, Proteomic Profile, And Genotoxicity, Leidiane Alencar De Oliveira Lima, Giza Hellen Nonato Miranda, Walessa Alana Bragança Aragão, Leonardo Oliveira Bittencourt, Sávio Monteiro Dos Santos, Michel Platini Caldas De Souza, Lygia S. Nogueira, Edivaldo Herculano Corrêa De Oliveira, Marta Chagas Monteiro, Aline Dionizio, Aline Lima Leite, Juliano Pelim Pessan, Marília Afonso Rabelo Buzalaf, Rafael Rodrigues Lima

Chemistry Department: Faculty Publications

Although fluoride (F) is well-known to prevent dental caries, changes in cell processes in different tissues have been associated with its excessive exposure. Thus, this study aimed to evaluate the effects of F exposure on biochemical, proteomic, and genotoxic parameters of submandibular glands. Twenty one old rats (n = 30) were allocated into three groups: 60 days administration of drinking water containing 10 mgF/L, 50 mgF/L, or only deionized water (control). The submandibular glands were collected for oxidative biochemistry, protein expression profile, and genotoxic potential analyses. The results showed that both F concentrations increased the levels of thiobarbituric acid–reactive …

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Thermolysis Of Hypervalent Iodine Complexes: Synthesis Of Fluorinated Radiotracers For Positron Emission Tomography And Synthesis Of Quaternary Α-Alkyl Α-Aryl Amino Acids, Jayson J. Kempinger

Department of Chemistry: Dissertations, Theses, and Student Research

Hypervalent iodine complexes can be used to deliver a variety of functional groups to arenes. Delivery of fluorine‑18, in a manner compatible with positron emission tomography (PET), is especially attractive. Vizamyl^TM, an injectable solution of [¹⁸F]Flutemetamol, is currently used to diagnose and monitor the progression of Alzheimer’s Disease (AD), the most common form of dementia. AD affects 47.5 million people across the world as of 2015, and is projected to affect 1 in 85 people by 2050. An improved radiosynthesis of [¹⁸F]Flutemetamol via a diaryliodonium salt is described. The use of nonpolar solvents minimizes …

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The 8-Silyloxyquinoline Scaffold As A Versatile Platform For The Sensitive Detection Of Aqueous Fluoride, Xinqi Zhou

Department of Chemistry: Dissertations, Theses, and Student Research

As one of the most essential elements in nature, fluoride has been well known and extensively studied since the 16^th century. Since then the two-edged nature of fluoride in biological systems has been well described. Specifically, moderate fluoride exposure can aid in tooth and bone development, while fluoride overexposure results in the depilating disease known as fluorosis. Because of the side effects upon overexposure of fluoride, there is a need to develop fast and straight forward methods to sensitively and selectively detect and quantify fluoride concentration in drinking water. With this goal in mind and by taking advantage of …

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The Effect Of Non-Fluoride Factors On Risk Of Dental Fluorosis: Evidence From Rural Populations Of The Main Ethiopian Rift, Julia Kravchenko, Tewodros Rango, Igor Akushevich, Behailu Atlaw, Peter G. Mccornick, R. Brittany Merola, Christopher Paul, Erika Weinthal, Courtney Harrison, Avner Vengosh, Marc Jeuland

Daugherty Water for Food Global Institute: Faculty Publications

Elevated level of fluoride (F⁻) in drinking water is a well-recognized risk factor of dental fluorosis (DF). While considering optimization of region-specific standards for F⁻, it is reasonable, however, to consider how local diet, water sourcing practices, and non-F⁻ elements in water may be related to health outcomes. In this study, we hypothesized that non-F⁻ elements in groundwater and lifestyle and demographic characteristics may be independent predictors or modifiers of the effects of F⁻ on teeth. Dental examinations were conducted among 1094 inhabitants from 399 randomly selected households of 20 rural communities of …

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Groundwater Quality And Its Health Impact: An Assessment Of Dental Fluorosis In Rural Inhabitants Of The Main Ethiopian Rift, Tewodros Rango, Julia Kravchenko, Behailu Atlaw, Peter G. Mccornick, Marc Jeuland, Brittany Merola, Avner Vengosh

Daugherty Water for Food Global Institute: Faculty Publications

This study aims to assess the link between fluoride content in groundwater and its impact on dental health in rural communities of the Ethiopian Rift. A total of 148 water samples were collected from two drainage basins within the Main Ethiopian Rift (MER). In the Ziway-Shala basin in particular, wells had high fluoride levels (mean: 9.4 ± 10.5 mg/L; range: 1.1 to 68 mg/L), with 48 of 50 exceeding the WHO drinking water guideline limit of 1.5 mg/L. Total average daily intake of fluoride from drinking groundwater (calculated per weight unit) was also found to be six times higher than …

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Full-Text Articles in Physical Sciences and Mathematics

Chemistry Department: Faculty Publications

Thermolysis Of Hypervalent Iodine Complexes: Synthesis Of Fluorinated Radiotracers For Positron Emission Tomography And Synthesis Of Quaternary Α-Alkyl Α-Aryl Amino Acids, Jayson J. Kempinger

Department of Chemistry: Dissertations, Theses, and Student Research

The 8-Silyloxyquinoline Scaffold As A Versatile Platform For The Sensitive Detection Of Aqueous Fluoride, Xinqi Zhou

Department of Chemistry: Dissertations, Theses, and Student Research

Daugherty Water for Food Global Institute: Faculty Publications

Groundwater Quality And Its Health Impact: An Assessment Of Dental Fluorosis In Rural Inhabitants Of The Main Ethiopian Rift, Tewodros Rango, Julia Kravchenko, Behailu Atlaw, Peter G. Mccornick, Marc Jeuland, Brittany Merola, Avner Vengosh

Daugherty Water for Food Global Institute: Faculty Publications