Physical Sciences and Mathematics Commons^™

Statistical Methodology To Establish A Benchmark For Evaluating Antimicrobial Resistance Genes Through Real Time Pcr Assay, Enakshy Dutta

Department of Statistics: Dissertations, Theses, and Student Work

Novel diagnostic tests are usually compared with gold standard tests for evaluating diagnostic accuracy. For assessing antimicrobial resistance (AMR) to bovine respiratory disease (BRD) pathogens, phenotypic broth microdilution method is used as gold standard (GS). The objective of the thesis is to evaluate the optimal cycle threshold (Ct) generated by real-time polymerase chain reaction (rtPCR) to genes that confer resistance that will translate to the phenotypic classification of AMR. Data from two different methodologies are assessed to identify Ct that will discriminate between resistance (R) and susceptibility (S). First, the receiver operating characteristic (ROC) curve was used to determine the …

Using Stability To Select A Shrinkage Method, Dean Dustin

Department of Statistics: Dissertations, Theses, and Student Work

Shrinkage methods are estimation techniques based on optimizing expressions to find which variables to include in an analysis, typically a linear regression. The general form of these expressions is the sum of an empirical risk plus a complexity penalty based on the number of parameters. Many shrinkage methods are known to satisfy an ‘oracle’ property meaning that asymptotically they select the correct variables and estimate their coefficients efficiently. In Section 1.2, we show oracle properties in two general settings. The first uses a log likelihood in place of the empirical risk and allows a general class of penalties. The second …

Community Impact On The Home Advantage Within Ncaa Men's Basketball, Erin O'Donnell

Department of Statistics: Dissertations, Theses, and Student Work

The home advantage is a commonly accepted truth throughout sports performances. This paper investigates the magnitude of the home advantage among NCAA Men’s Basketball teams. It will then look to draw relationships between the magnitude of the home advantage and community aspects such as attendance, location, past program success, and social media presence. Univariate and Multivariate models will be investigated.

Advisor: Walter S Stroup

Group Testing Identification: Objective Functions, Implementation, And Multiplex Assays, Brianna D. Hitt

Department of Statistics: Dissertations, Theses, and Student Work

Group testing is the process of combining items into groups to test for a binary characteristic. One of its most widely used applications is infectious disease testing. In this context, specimens (e.g., blood, urine) are amalgamated into groups and tested. For groups that test positive, there are many algorithmic retesting procedures available to identify positive individuals. The appeal of group testing is that the overall number of tests needed is significantly less than for individual testing when disease prevalence is small and an appropriate algorithm is chosen. Group testing has a number of applications beyond infectious disease testing, such as …