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Mefenamic Acid – Hpmc As Hg Amorphous Solid Dispersions: Dissolution Enhancement Using Hot Melt Extrusion Technology, Ashay Shukla
Mefenamic Acid – Hpmc As Hg Amorphous Solid Dispersions: Dissolution Enhancement Using Hot Melt Extrusion Technology, Ashay Shukla
Electronic Theses and Dissertations
Mefenamic acid, a BCS class II drug, displays high permeability and low solubility, thereby exhibiting a poor dissolution profile. Hence to improve the solubility and dissolution rate of Mefenamic acid, Hot Melt Extrusion (HME) technique was employed. The amorphous solid dispersion matrix exhibited enhanced dissolution with desired release characteristics. Hydroxypropylmethylcellulose acetate succinate (AquaSolve™ HPMC-AS HG) was used as a carrier with the poloxamer (Kolliphor P407). The drug load was varied from 20% to 40% within the blend. Drug and polymers were blended using a twin shell V-blender for 10 minutes and extruded using an 11mm twin-screw co-rotating extruder (ThermoFisher Scientific, …