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Full-Text Articles in Physical Sciences and Mathematics
Alcohol Consumption And Breast Tumor Gene Expression, Jun Wang, Yujing J. Heng, A. Heather Eliassen, Rull M. Tamimi, Aditi Hazra, Vincent J. Carey, Christine B. Ambrosone, Victor P. De Andrade, Adam Brufsky, Fergus J. Couch, Tari A. King, Francesmary Modugno, Celine M. Vachon, David J. Hunter, Andrew H. Beck, Susan E. Hankinson
Alcohol Consumption And Breast Tumor Gene Expression, Jun Wang, Yujing J. Heng, A. Heather Eliassen, Rull M. Tamimi, Aditi Hazra, Vincent J. Carey, Christine B. Ambrosone, Victor P. De Andrade, Adam Brufsky, Fergus J. Couch, Tari A. King, Francesmary Modugno, Celine M. Vachon, David J. Hunter, Andrew H. Beck, Susan E. Hankinson
Biostatistics and Epidemiology Faculty Publications Series
Background
Alcohol consumption is an established risk factor for breast cancer and the association generally appears stronger among estrogen receptor (ER)-positive tumors. However, the biological mechanisms underlying this association are not completely understood.
Methods
We analyzed messenger RNA (mRNA) microarray data from both invasive breast tumors (N = 602) and tumor-adjacent normal tissues (N = 508) from participants diagnosed with breast cancer in the Nurses’ Health Study (NHS) and NHSII. Multivariable linear regression, controlling for other known breast cancer risk factors, was used to identify differentially expressed genes by pre-diagnostic alcohol intake. For pathway analysis, we performed gene …