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Articles 1 - 30 of 248
Full-Text Articles in Physical Sciences and Mathematics
Post-Wildfire Recovery Of An Upland Oak-Pine Forest On The Cumberland Plateau, Kentucky, Usa, Devin E. Black, Zachary W. Poynter, Claudia A. Cotton, Suraj Upadhaya, David D. Taylor, Wendy Leuenberger, Beth A. Blankenship, Mary A. Arthur
Post-Wildfire Recovery Of An Upland Oak-Pine Forest On The Cumberland Plateau, Kentucky, Usa, Devin E. Black, Zachary W. Poynter, Claudia A. Cotton, Suraj Upadhaya, David D. Taylor, Wendy Leuenberger, Beth A. Blankenship, Mary A. Arthur
Forestry and Natural Resources Faculty Publications
Background: Many forests within the southern Appalachian region, USA, have experienced decades of fire exclusion, contributing to regeneration challenges for species such as oaks (Quercus spp. L.) and pines (Pinus spp. L.), and threatening the maintenance of oak-dominated forests in the future. While the use of prescribed fire as a forest management tool is increasing within this region, there remains a lack of information on the potential role of wildfire. A wildfire within the Daniel Boone National Forest, Kentucky, USA, provided an opportunity to investigate how wildfire affected forest vegetation response.
Results: We examined the effects of fire …
Decays Of Pentaquarks In Hadrocharmonium And Molecular Scenarios, Michael I. Eides, Victor Yu. Petrov
Decays Of Pentaquarks In Hadrocharmonium And Molecular Scenarios, Michael I. Eides, Victor Yu. Petrov
Physics and Astronomy Faculty Publications
We consider decays of the hidden charm LHCb pentaquarks in the hadrocharmonium and molecular scenarios. In both pictures the LHCb pentaquarks are essentially nonrelativistic bound states. We develop a semirelativistic framework for calculation of the partial decay widths that allows the final particles to be relativistic. Using this approach we calculate the decay widths in the hadrocharmonium and molecular pictures. Molecular hidden charm pentaquarks are constructed as loosely bound states of charmed and anticharmed hadrons. Calculations show that molecular pentaquarks decay predominantly into states with open charm. Strong suppression of the molecular pentaquark decays into states with hidden charm is …
Discerning Novel Splice Junctions Derived From Rna-Seq Alignment: A Deep Learning Approach, Yi Zhang, Xinan Liu, James N. Macleod, Jinze Liu
Discerning Novel Splice Junctions Derived From Rna-Seq Alignment: A Deep Learning Approach, Yi Zhang, Xinan Liu, James N. Macleod, Jinze Liu
Computer Science Faculty Publications
Background: Exon splicing is a regulated cellular process in the transcription of protein-coding genes. Technological advancements and cost reductions in RNA sequencing have made quantitative and qualitative assessments of the transcriptome both possible and widely available. RNA-seq provides unprecedented resolution to identify gene structures and resolve the diversity of splicing variants. However, currently available ab initio aligners are vulnerable to spurious alignments due to random sequence matches and sample-reference genome discordance. As a consequence, a significant set of false positive exon junction predictions would be introduced, which will further confuse downstream analyses of splice variant discovery and abundance estimation.
Results: …
Quantifying Bee Assemblages And Attractiveness Of Flowering Woody Landscape Plants For Urban Pollinator Conservation, Bernadette M. Mach, Daniel A. Potter
Quantifying Bee Assemblages And Attractiveness Of Flowering Woody Landscape Plants For Urban Pollinator Conservation, Bernadette M. Mach, Daniel A. Potter
Entomology Faculty Publications
Urban and suburban landscapes can be refuges for biodiversity of bees and other pollinators. Public awareness of declining pollinator populations has increased interest in growing plants that provide floral resources for bees. Various publications and websites list “bee-friendly” plants, but such lists are rarely based on empirical data, nor do they emphasize flowering trees and shrubs, which are a major component of urban landscapes. We quantified bee visitation to 72 species of flowering woody landscape plants across 373 urban and suburban sites in Kentucky and southern Ohio, USA, sampling and identifying the bee assemblages associated with 45 of the most …
Improved Measurement Of The Longitudinal Spin Transfer To Λ And Λ¯ Hyperons In Polarized Proton-Proton Collisions At √S = 200 Gev, J. Adam, L. Adamczyk, J. R. Adams, James K. Adkins, G. Agakishiev, M. M. Aggarwal, Z. Ahammed, I. Alekseev, D. M. Anderson, R. Aoyama, A. Aparin, D. Arkhipkin, E. C. Aschenauer, M. U. Ashraf, F. Atetalla, A. Attri, G. S. Averichev, X. Bai, V. Bairathi, K. Barish, A. J. Bassill, A. Behera, R. Bellwied, A. Bhasin, A. K. Bhati, J. Bielcik, J. Bielcikova, L. C. Bland, I. G. Bordyuzhin, J. D. Brandenburg, Renee H. Fatemi, Suvarna Ramachandran
Improved Measurement Of The Longitudinal Spin Transfer To Λ And Λ¯ Hyperons In Polarized Proton-Proton Collisions At √S = 200 Gev, J. Adam, L. Adamczyk, J. R. Adams, James K. Adkins, G. Agakishiev, M. M. Aggarwal, Z. Ahammed, I. Alekseev, D. M. Anderson, R. Aoyama, A. Aparin, D. Arkhipkin, E. C. Aschenauer, M. U. Ashraf, F. Atetalla, A. Attri, G. S. Averichev, X. Bai, V. Bairathi, K. Barish, A. J. Bassill, A. Behera, R. Bellwied, A. Bhasin, A. K. Bhati, J. Bielcik, J. Bielcikova, L. C. Bland, I. G. Bordyuzhin, J. D. Brandenburg, Renee H. Fatemi, Suvarna Ramachandran
Physics and Astronomy Faculty Publications
The longitudinal spin transfer DLL to Λ and Λ¯ hyperons produced in high-energy polarized proton-proton collisions is expected to be sensitive to the helicity distribution functions of strange quarks and antiquarks of the proton, and to longitudinally polarized fragmentation functions. We report an improved measurement of DLL from data obtained at a center-of-mass energy of √s = 200 GeV with the STAR detector at RHIC. The data have an approximately twelve times larger figure of merit than prior results and cover |η| < 1.2 in pseudorapidity with transverse momenta pT up to 6 GeV/c. In the forward scattering hemisphere …
The Catalytic Mechanism Of Electron-Bifurcating Electron Transfer Flavoproteins (Etfs) Involves An Intermediary Complex With Nad+, Gerrit J. Schut, Nishya Mohamed-Raseek, Monika Tokmina-Lukaszewska, David W. Mulder, Diep M. N. Nguyen, Gina L. Lipscomb, John Patrick Hoben, Angela Patterson, Carolyn E. Lubner, Paul W. King, John W. Peters, Brian Bothner, Anne-Frances Miller, Michael W. W. Adams
The Catalytic Mechanism Of Electron-Bifurcating Electron Transfer Flavoproteins (Etfs) Involves An Intermediary Complex With Nad+, Gerrit J. Schut, Nishya Mohamed-Raseek, Monika Tokmina-Lukaszewska, David W. Mulder, Diep M. N. Nguyen, Gina L. Lipscomb, John Patrick Hoben, Angela Patterson, Carolyn E. Lubner, Paul W. King, John W. Peters, Brian Bothner, Anne-Frances Miller, Michael W. W. Adams
Chemistry Faculty Publications
Electron bifurcation plays a key role in anaerobic energy metabolism, but it is a relatively new discovery, and only limited mechanistic information is available on the diverse enzymes that employ it. Herein, we focused on the bifurcating electron transfer flavoprotein (ETF) from the hyperthermophilic archaeon Pyrobaculum aerophilum. The EtfABCX enzyme complex couples NADH oxidation to the endergonic reduction of ferredoxin and exergonic reduction of menaquinone. We developed a model for the enzyme structure by using nondenaturing MS, cross-linking, and homology modeling in which EtfA, -B, and -C each contained FAD, whereas EtfX contained two [4Fe-4S] clusters. On the basis …
Dichotomous Scoring Of Tdp-43 Proteinopathy From Specific Brain Regions In 27 Academic Research Centers: Associations With Alzheimer's Disease And Cerebrovascular Disease Pathologies, Yuriko Katsumata, David W. Fardo, Walter A. Kukull, Peter T. Nelson
Dichotomous Scoring Of Tdp-43 Proteinopathy From Specific Brain Regions In 27 Academic Research Centers: Associations With Alzheimer's Disease And Cerebrovascular Disease Pathologies, Yuriko Katsumata, David W. Fardo, Walter A. Kukull, Peter T. Nelson
Biostatistics Faculty Publications
TAR-DNA binding protein 43 (TDP-43) proteinopathy is a common brain pathology in elderly persons, but much remains to be learned about this high-morbidity condition. Published stage-based systems for operationalizing disease severity rely on the involvement (presence/absence) of pathology in specific anatomic regions. To examine the comorbidities associated with TDP-43 pathology in aged individuals, we studied data from the National Alzheimer’s Coordinating Center (NACC) Neuropathology Data Set. Data were analyzed from 929 included subjects with available TDP-43 pathology information, sourced from 27 different American Alzheimer’s Disease Centers (ADCs). Cases with relatively unusual diseases including autopsy-proven frontotemporal lobar degeneration (FTLD-TDP or FTLD-tau) …
Large-Scale Genome-Wide Meta-Analysis Of Polycystic Ovary Syndrome Suggests Shared Genetic Architecture For Different Diagnosis Criteria, Felix Day, Tugce Karaderi, Michelle R. Jones, Cindy Meun, Chunyan He, Alex Drong, Peter Kraft, Nan Lin, Hongyan Huang, Linda Broer, Reedik Magi, Richa Saxena, Triin Laisk, Margrit Urbanek, M. Geoffrey Hayes, Gudmar Thorleifsson, Juan Fernandez-Tajes, Anubha Mahajan, Benjamin H. Mullin, Bronwyn G. A. Stuckey, Timothy D. Spector, Scott G. Wilson, Mark O. Goodarzi, Lea Davis, Barbara Obermayer-Pietsch, André G. Uitterlinden, Verneri Anttila, Benjamin M. Neale, Marjo-Riitta Jarvelin, Bart Fauser
Large-Scale Genome-Wide Meta-Analysis Of Polycystic Ovary Syndrome Suggests Shared Genetic Architecture For Different Diagnosis Criteria, Felix Day, Tugce Karaderi, Michelle R. Jones, Cindy Meun, Chunyan He, Alex Drong, Peter Kraft, Nan Lin, Hongyan Huang, Linda Broer, Reedik Magi, Richa Saxena, Triin Laisk, Margrit Urbanek, M. Geoffrey Hayes, Gudmar Thorleifsson, Juan Fernandez-Tajes, Anubha Mahajan, Benjamin H. Mullin, Bronwyn G. A. Stuckey, Timothy D. Spector, Scott G. Wilson, Mark O. Goodarzi, Lea Davis, Barbara Obermayer-Pietsch, André G. Uitterlinden, Verneri Anttila, Benjamin M. Neale, Marjo-Riitta Jarvelin, Bart Fauser
Internal Medicine Faculty Publications
Polycystic ovary syndrome (PCOS) is a disorder characterized by hyperandrogenism, ovulatory dysfunction and polycystic ovarian morphology. Affected women frequently have metabolic disturbances including insulin resistance and dysregulation of glucose homeostasis. PCOS is diagnosed with two different sets of diagnostic criteria, resulting in a phenotypic spectrum of PCOS cases. The genetic similarities between cases diagnosed based on the two criteria have been largely unknown. Previous studies in Chinese and European subjects have identified 16 loci associated with risk of PCOS. We report a fixed-effect, inverse-weighted-variance meta-analysis from 10,074 PCOS cases and 103,164 controls of European ancestry and characterisation of PCOS related …
Detecting Radio Agn Signatures In Red Geysers, Namrata Roy, Kevin Bundy, Wiphu Rujopakarn, Michele Cappellari, Francesco Belfiore, Renbin Yan, Tim Heckman, Matthew Bershady, Jenny Greene, Kyle Westfall, Niv Drory, Kate Rubin, David Law, Kai Zhang, Joseph Gelfand, Dmitry Bizyaev, David Wake, Karen Masters, Daniel Thomas, Cheng Li, Rogemar A. Riffel
Detecting Radio Agn Signatures In Red Geysers, Namrata Roy, Kevin Bundy, Wiphu Rujopakarn, Michele Cappellari, Francesco Belfiore, Renbin Yan, Tim Heckman, Matthew Bershady, Jenny Greene, Kyle Westfall, Niv Drory, Kate Rubin, David Law, Kai Zhang, Joseph Gelfand, Dmitry Bizyaev, David Wake, Karen Masters, Daniel Thomas, Cheng Li, Rogemar A. Riffel
Physics and Astronomy Faculty Publications
A new class of quiescent galaxies harboring possible AGN-driven winds has been discovered using spatially resolved optical spectroscopy from the ongoing SDSS-IV MaNGA survey. These galaxies, termed "red geysers," constitute 5%–10% of the local quiescent population and are characterized by narrow bisymmetric patterns in ionized gas emission features. Cheung et al. argued that these galaxies host large-scale AGN-driven winds that may play a role in suppressing star formation at late times. In this work, we test the hypothesis that AGN activity is ultimately responsible for the red geyser phenomenon. We compare the nuclear radio activity of the red geysers to …
Spoil Type Influences Soil Genesis And Forest Development On An Appalachian Surface Coal Mine Ten Years After Placement, Kenton L. Sena, Carmen T. Agouridis, Jarrod Miller, Christopher D. Barton
Spoil Type Influences Soil Genesis And Forest Development On An Appalachian Surface Coal Mine Ten Years After Placement, Kenton L. Sena, Carmen T. Agouridis, Jarrod Miller, Christopher D. Barton
Lewis Honors College Faculty Publications
Surface mining for coal (or other mineral resources) is a major driver of land-use change around the world and especially in the Appalachian region of the United States. Intentional and well-informed reclamation of surface-mined land is critical for the restoration of healthy ecosystems on these disturbed sites. In Appalachia, the pre-mining land cover is predominately mixed hardwood forest, with rich species diversity. In recent years, Appalachian mine reforestation has become an issue of concern, prompting the development of the Forestry Reclamation Approach, a series of mine reforestation recommendations. One of these recommendations is to use the best available soil substitute; …
Mass-Analyzed Threshold Ionization Of Lanthanide Imide Lnnh (Ln = La And Ce) Radicals From N–H Bond Activation Of Ammonia, Yuchen Zhang, Silver Nyambo, Dong-Sheng Yang
Mass-Analyzed Threshold Ionization Of Lanthanide Imide Lnnh (Ln = La And Ce) Radicals From N–H Bond Activation Of Ammonia, Yuchen Zhang, Silver Nyambo, Dong-Sheng Yang
Chemistry Faculty Publications
Ln (Ln = La and Ce) atom reactions with ammonia are carried out in a pulsed laser vaporization supersonic molecular beam source. Lanthanide-containing species are observed with time-of-flight mass spectrometry, and LnNH molecules are characterized by mass-analyzed threshold ionization (MATI) spectroscopy and quantum chemical calculations. The theoretical calculations include density functional theory for both Ln species and a scalar relativity correction, electron correlation, and spin-orbit coupling for the Ce species. The MATI spectrum of LaNH exhibits a single vibronic band system with a strong origin band and two weak vibronic progressions, whereas the spectrum of CeNH displays two band systems …
Coordinated Unmanned Aircraft System (Uas) And Ground-Based Weather Measurements To Predict Lagrangian Coherent Structures (Lcss), Peter J. Nolan, James Pinto, Javier González-Rocha, Anders Jensen, Christina N. Vezzi, Sean C. C. Bailey, Gijs De Boer, Constantin Diehl, Roger Laurence Iii, Craig W. Powers, Hosein Foroutan, Shane D. Ross, David G. Schmale Iii
Coordinated Unmanned Aircraft System (Uas) And Ground-Based Weather Measurements To Predict Lagrangian Coherent Structures (Lcss), Peter J. Nolan, James Pinto, Javier González-Rocha, Anders Jensen, Christina N. Vezzi, Sean C. C. Bailey, Gijs De Boer, Constantin Diehl, Roger Laurence Iii, Craig W. Powers, Hosein Foroutan, Shane D. Ross, David G. Schmale Iii
Mechanical Engineering Faculty Publications
Concentrations of airborne chemical and biological agents from a hazardous release are not spread uniformly. Instead, there are regions of higher concentration, in part due to local atmospheric flow conditions which can attract agents. We equipped a ground station and two rotary-wing unmanned aircraft systems (UASs) with ultrasonic anemometers. Flights reported here were conducted 10 to 15 m above ground level (AGL) at the Leach Airfield in the San Luis Valley, Colorado as part of the Lower Atmospheric Process Studies at Elevation—a Remotely-Piloted Aircraft Team Experiment (LAPSE-RATE) campaign in 2018. The ultrasonic anemometers were used to collect simultaneous measurements of …
Serum Nutrient Levels And Aging Effects On Periodontitis, Jeffrey L Ebersole, Joshua Lambert, Heather Bush, Pinar Emecen Huja, Arpita Basu
Serum Nutrient Levels And Aging Effects On Periodontitis, Jeffrey L Ebersole, Joshua Lambert, Heather Bush, Pinar Emecen Huja, Arpita Basu
Biostatistics Faculty Publications
Periodontal disease damages tissues as a result of dysregulated host responses against the chronic bacterial biofilm insult and approximately 50% of US adults > 30 years old exhibit periodontitis. The association of five blood nutrients and periodontitis were evaluated due to our previous findings regarding a potential protective effect for these nutrients in periodontal disease derived from the US population sampled as part of the National Health and Nutrition Examination Survey (1999–2004). Data from over 15,000 subjects was analyzed for blood levels of cis-β-carotene, β-cryptoxanthin, folate, vitamin D, and vitamin E, linked with analysis of the presence and severity of periodontitis. …
First Observation Of P-Odd Γ Asymmetry In Polarized Neutron Capture On Hydrogen, D. Blyth, J. Fry, N. Fomin, R. Alarcon, L. Alonzi, E. Askanazi, S. Baeßler, S. Balascuta, L. Barrón-Palos, A. Barzilov, J. D. Bowman, N. Birge, J. R. Calarco, T. E. Chupp, V. Cianciolo, C. E. Coppola, Chrisopher B. Crawford, K. Craycraft, D. Evans, C. Fieseler, E. Frlež, I. Garishvili, M. T. W. Gericke, R. C. Gillis, K. B. Grammer, G. L. Greene, J. Hall, J. Hamblen, C. Hayes, E. B. Iverson, Md Latiful Kabir, Mark Mccrea, R. Milburn, F. Simmons, Aaron P. Sprow, E. Tang
First Observation Of P-Odd Γ Asymmetry In Polarized Neutron Capture On Hydrogen, D. Blyth, J. Fry, N. Fomin, R. Alarcon, L. Alonzi, E. Askanazi, S. Baeßler, S. Balascuta, L. Barrón-Palos, A. Barzilov, J. D. Bowman, N. Birge, J. R. Calarco, T. E. Chupp, V. Cianciolo, C. E. Coppola, Chrisopher B. Crawford, K. Craycraft, D. Evans, C. Fieseler, E. Frlež, I. Garishvili, M. T. W. Gericke, R. C. Gillis, K. B. Grammer, G. L. Greene, J. Hall, J. Hamblen, C. Hayes, E. B. Iverson, Md Latiful Kabir, Mark Mccrea, R. Milburn, F. Simmons, Aaron P. Sprow, E. Tang
Physics and Astronomy Faculty Publications
We report the first observation of the parity-violating gamma-ray asymmetry Anpγ in neutron-proton capture using polarized cold neutrons incident on a liquid parahydrogen target at the Spallation Neutron Source at Oak Ridge National Laboratory. Anpγ isolates the ΔI = 1, 3S1 → 3P1 component of the weak nucleon-nucleon interaction, which is dominated by pion exchange and can be directly related to a single coupling constant in either the DDH meson exchange model or pionless effective field theory. We measured Anpγ = [−3.0 ± 1.4(stat )± 0.2(syst)] × 10−8 …
Dynamics Of Postfire Aboveground Carbon In A Chronosequence Of Chinese Boreal Larch Forests, Yuan Z. Yang, Wen H. Cai, Jian Yang, Megan White, John M. Lhotka
Dynamics Of Postfire Aboveground Carbon In A Chronosequence Of Chinese Boreal Larch Forests, Yuan Z. Yang, Wen H. Cai, Jian Yang, Megan White, John M. Lhotka
Forestry and Natural Resources Faculty Publications
Boreal forests store a large proportion of the global terrestrial carbon (C), while wildfire plays a crucial role in determining their C storage and dynamics. The aboveground C (AC) pool is an important component of forest C stocks. To quantify the turning point (transforming from C source to C sink) and recovery time of postfire AC, and assess how stand density affects the AC, 175 plots from eight stand age classes were surveyed as a chronosequence in the Great Xing'an Mountains of Northeast China. Linear and nonlinear regression analyses were conducted to describe postfire AC recovery patterns. The results showed …
Understory Community Assembly Following Wildfire In Boreal Forests: Shift From Stochasticity To Competitive Exclusion And Environmental Filtering, Bo Liu, Han Y. H. Chen, Jian Yang
Understory Community Assembly Following Wildfire In Boreal Forests: Shift From Stochasticity To Competitive Exclusion And Environmental Filtering, Bo Liu, Han Y. H. Chen, Jian Yang
Forestry and Natural Resources Faculty Publications
Understory vegetation accounts for the majority of plant species diversity and serves as a driver of overstory succession and nutrient cycling in boreal forest ecosystems. However, investigations of the underlying assembly processes of understory vegetation associated with stand development following a wildfire disturbance are rare, particularly in Eurasian boreal forests. In this study, we measured the phylogenetic and functional diversity and trait dispersions of understory communities and tested how these patterns changed with stand age in the Great Xing'an Mountains of Northeastern China. Contrary to our expectation, we found that understory functional traits were phylogenetically convergent. We found that random …
Leveraging Student Experience With Water For Active Learning In A Large Introductory Oceanography Classroom, Rebecca Freeman
Leveraging Student Experience With Water For Active Learning In A Large Introductory Oceanography Classroom, Rebecca Freeman
Earth and Environmental Sciences Faculty Publications
No abstract provided.
Non-Aqueous Redox Flow Batteries Including 3,7-Perfluoroalkylated Phenothiazine Derivatives, Susan A. Odom, Aman Preet Kaur, Corrine F. Elliott, Matthew D. Casselman
Non-Aqueous Redox Flow Batteries Including 3,7-Perfluoroalkylated Phenothiazine Derivatives, Susan A. Odom, Aman Preet Kaur, Corrine F. Elliott, Matthew D. Casselman
Chemistry Faculty Patents
A non-aqueous redox flow battery includes a negative electrode immersed in a first non-aqueous liquid electrolyte solution, a positive electrode immersed in a second nonaqueous liquid electrolyte solution, and a semi-permeable separator interposed between the negative and positive electrodes, wherein the second the non-aqueous liquid electrolyte solution comprises a compound of the formula...
To see the remainder of this abstract, please download this patent.
Gluon Quasi-Parton-Distribution Functions From Lattice Qcd, Zhou-You Fan, Yi-Bo Yang, Adam Anthony, Huey-Wen Lin, Keh-Fei Liu
Gluon Quasi-Parton-Distribution Functions From Lattice Qcd, Zhou-You Fan, Yi-Bo Yang, Adam Anthony, Huey-Wen Lin, Keh-Fei Liu
Physics and Astronomy Faculty Publications
We present the first attempt to access the x dependence of the gluon unpolarized parton-distribution function (PDF), based on lattice simulations using the large-momentum effective theory approach. The lattice calculation is carried out with pion masses of 340 and 678 MeV on a (2+1)-flavor domain-wall fermion configuration with lattice spacing a = 0.111 fm, for the gluon quasi-PDF matrix element with the nucleon momentum up to 0.93 GeV. Taking the normalization from similar matrix elements in the rest frame of the nucleon and pion, our results for these matrix elements are consistent with the Fourier transform of the global fit …
A Logitudinal Feature Selection Method Identifies Relevant Genes To Distinguish Complicated Injury And Uncomplicated Injury Over Time, Suyan Tian, Chi Wang, Howard H. Chang
A Logitudinal Feature Selection Method Identifies Relevant Genes To Distinguish Complicated Injury And Uncomplicated Injury Over Time, Suyan Tian, Chi Wang, Howard H. Chang
Biostatistics Faculty Publications
Background: Feature selection and gene set analysis are of increasing interest in the field of bioinformatics. While these two approaches have been developed for different purposes, we describe how some gene set analysis methods can be utilized to conduct feature selection.
Methods: We adopted a gene set analysis method, the significance analysis of microarray gene set reduction (SAMGSR) algorithm, to carry out feature selection for longitudinal gene expression data.
Results: Using a real-world application and simulated data, it is demonstrated that the proposed SAMGSR extension outperforms other relevant methods. In this study, we illustrate that a gene’s expression profiles over …
Canvass: A Crowd-Sourced, Natural-Product Screening Library For Exploring Biological Space, Sara E. Kearney, Gergely ZahoráNszky-KőHalmi, Kyle R. Brimacombe, Mark J. Henderson, Caitlin Lynch, Tongan Zhao, Kanny K. Wan, Zina Itkin, Christopher Dillon, Min Shen, Dorian M. Cheff, Tobie D. Lee, Danielle Bougie, Ken Cheng, Nathan P. Coussens, Dorjbal Dorjsuren, Richard T. Eastman, Ruili Huang, Michael J. Iannotti, Surendra Karavadhi, Carleen Klumpp-Thomas, Jacob S. Roth, Srilatha Sakamuru, Wei Sun, Steven A. Titus, Adam Yasgar, Ya-Qin Zhang, Jinghua Zhao, Rodrigo B. Andrade, M. Kevin Brown, Robert B. Grossman
Canvass: A Crowd-Sourced, Natural-Product Screening Library For Exploring Biological Space, Sara E. Kearney, Gergely ZahoráNszky-KőHalmi, Kyle R. Brimacombe, Mark J. Henderson, Caitlin Lynch, Tongan Zhao, Kanny K. Wan, Zina Itkin, Christopher Dillon, Min Shen, Dorian M. Cheff, Tobie D. Lee, Danielle Bougie, Ken Cheng, Nathan P. Coussens, Dorjbal Dorjsuren, Richard T. Eastman, Ruili Huang, Michael J. Iannotti, Surendra Karavadhi, Carleen Klumpp-Thomas, Jacob S. Roth, Srilatha Sakamuru, Wei Sun, Steven A. Titus, Adam Yasgar, Ya-Qin Zhang, Jinghua Zhao, Rodrigo B. Andrade, M. Kevin Brown, Robert B. Grossman
Chemistry Faculty Publications
Natural products and their derivatives continue to be wellsprings of nascent therapeutic potential. However, many laboratories have limited resources for biological evaluation, leaving their previously isolated or synthesized compounds largely or completely untested. To address this issue, the Canvass library of natural products was assembled, in collaboration with academic and industry researchers, for quantitative high-throughput screening (qHTS) across a diverse set of cell-based and biochemical assays. Characterization of the library in terms of physicochemical properties, structural diversity, and similarity to compounds in publicly available libraries indicates that the Canvass library contains many structural elements in common with approved drugs. The …
A Simple And Robust Approach To Reducing Contact Resistance In Organic Transistors, Zachary A. Lamport, Katrina J. Barth, Hyunsu Lee, Eliot Gann, Sebastian Engmann, Hu Chen, Martin Guthold, Iain Mcculloch, John E. Anthony, Lee J. Richter, Dean M. Delongchamp, Oana D. Jurchescu
A Simple And Robust Approach To Reducing Contact Resistance In Organic Transistors, Zachary A. Lamport, Katrina J. Barth, Hyunsu Lee, Eliot Gann, Sebastian Engmann, Hu Chen, Martin Guthold, Iain Mcculloch, John E. Anthony, Lee J. Richter, Dean M. Delongchamp, Oana D. Jurchescu
Chemistry Faculty Publications
Efficient injection of charge carriers from the contacts into the semiconductor layer is crucial for achieving high-performance organic devices. The potential drop necessary to accomplish this process yields a resistance associated with the contacts, namely the contact resistance. A large contact resistance can limit the operation of devices and even lead to inaccuracies in the extraction of the device parameters. Here, we demonstrate a simple and efficient strategy for reducing the contact resistance in organic thin-film transistors by more than an order of magnitude by creating high work function domains at the surface of the injecting electrodes to promote channels …
Facepet: Enhancing Bystanders' Facial Privacy With Smart Wearables/Internet Of Things, Alfredo J. Perez, Sherali Zeadally, Luis Y. Matos Garcia, Jaouad A. Mouloud, Scott Griffith
Facepet: Enhancing Bystanders' Facial Privacy With Smart Wearables/Internet Of Things, Alfredo J. Perez, Sherali Zeadally, Luis Y. Matos Garcia, Jaouad A. Mouloud, Scott Griffith
Information Science Faculty Publications
Given the availability of cameras in mobile phones, drones and Internet-connected devices, facial privacy has become an area of major interest in the last few years, especially when photos are captured and can be used to identify bystanders’ faces who may have not given consent for these photos to be taken and be identified. Some solutions to protect facial privacy in photos currently exist. However, many of these solutions do not give a choice to bystanders because they rely on algorithms that de-identify photos or protocols to deactivate devices and systems not controlled by bystanders, thereby being dependent on the …
Breeding For Resilience To Increasing Temperatures: A Field Trial Assessing Genetic Variation In Soft Red Winter Wheat, Kathleen Russell, David Van Sanford
Breeding For Resilience To Increasing Temperatures: A Field Trial Assessing Genetic Variation In Soft Red Winter Wheat, Kathleen Russell, David Van Sanford
Plant and Soil Sciences Faculty Publications
Breeding for resilience to climate change is a daunting prospect. Crop and climate models tell us that global wheat yields are likely to decline as the climate warms, causing a significant risk to global food security. High temperatures are known to affect crop development yet breeding for tolerance to heat stress is difficult to achieve in field environments. We conducted an active warming study over two years to quantify the effects of heat stress on genetic variation of soft red winter (SRW) wheat (Triticum aestivum L.). Forty SRW cultivars and breeding lines were chosen based on marker genotypes at …
Data On Spectrum-Based Fluorescence Resonance Energy Transfer Measurement Of E. Coli Multidrug Transporter Acrb, Yuguang Cai, Thomas E. Wilkop, Yinan Wei
Data On Spectrum-Based Fluorescence Resonance Energy Transfer Measurement Of E. Coli Multidrug Transporter Acrb, Yuguang Cai, Thomas E. Wilkop, Yinan Wei
Chemistry Faculty Publications
This paper presented the dataset of correction parameters used in the determination of the energy transfer efficiencies from the spectrum-based fluorescence resonance energy transfer (FRET) measurement in a trimeric membrane protein AcrB. The cyan fluorescent protein (CFP) and yellow fluorescent protein (YPet) were used as the donor and acceptor, respectively. Two AcrB fusion proteins were constructed, AcrB-CFP and AcrB-YPet. The proteins were co-expressed in Escherichia coli cells, and energy transfer efficiency were determined in live cells. To obtain reliable energy transfer data, a complete set of correction parameters need to be first determined to accommodate for factors such as background …
Transverse Spin Transfer To Λ And Λ¯ Hyperons In Polarized Proton-Proton Collisions At √S = 200 Gev, J. Adam, L. Adamczyk, James K. Adkins, G. Agakishiev, M. M. Aggarwal, Z. Ahammed, I. Alekseev, D. M. Anderson, R. Aoyama, A. Aparin, D. Arkhipkin, E. C. Aschenauer, M. U. Ashraf, F. Atetalla, A. Attri, G. S. Averichev, X. Bai, V. Bairathi, K. Barish, A. J. Bassill, A. Behera, R. Bellwied, A. Bhasin, A. K. Bhati, J. Bielcik, J. Bielcikova, L. C. Bland, I. G. Bordyuzhin, J. D. Brandenburg, A. V. Brandin, Renee H. Fatemi, Suvarna Ramachandran
Transverse Spin Transfer To Λ And Λ¯ Hyperons In Polarized Proton-Proton Collisions At √S = 200 Gev, J. Adam, L. Adamczyk, James K. Adkins, G. Agakishiev, M. M. Aggarwal, Z. Ahammed, I. Alekseev, D. M. Anderson, R. Aoyama, A. Aparin, D. Arkhipkin, E. C. Aschenauer, M. U. Ashraf, F. Atetalla, A. Attri, G. S. Averichev, X. Bai, V. Bairathi, K. Barish, A. J. Bassill, A. Behera, R. Bellwied, A. Bhasin, A. K. Bhati, J. Bielcik, J. Bielcikova, L. C. Bland, I. G. Bordyuzhin, J. D. Brandenburg, A. V. Brandin, Renee H. Fatemi, Suvarna Ramachandran
Physics and Astronomy Faculty Publications
The transverse spin transfer from polarized protons to Λ and Λ¯ hyperons is expected to provide sensitivity to the transversity distribution of the nucleon and to the transversely polarized fragmentation functions. We report the first measurement of the transverse spin transfer to Λ and Λ¯ along the polarization direction of the fragmenting quark, DTT, in transversely polarized proton-proton collisions at √s = 200 GeV with the STAR detector at RHIC. The data correspond to an integrated luminosity of 18 pb−1 and cover the pseudorapidity range |η| < 1.2 and transverse momenta pT up to 8 GeV/c. …
Graphene Used As A Lateral Force Microscopy Calibration Material In The Low-Load Non-Linear Regime, Mathias J. Boland, Jacob L. Hempel, Armin Ansary, Mohsen Nasseri, Douglas R. Strachan
Graphene Used As A Lateral Force Microscopy Calibration Material In The Low-Load Non-Linear Regime, Mathias J. Boland, Jacob L. Hempel, Armin Ansary, Mohsen Nasseri, Douglas R. Strachan
Physics and Astronomy Faculty Publications
A lateral force microscopy (LFM) calibration technique utilizing a random low-profile surface is proposed that is successfully employed in the low-load non-linear frictional regime using a single layer of graphene on a supporting oxide substrate. This calibration at low loads and on low friction surfaces like graphene has the benefit of helping to limit the wear of the LFM tip during the calibration procedure. Moreover, the low-profiles of the calibration surface characteristic of these layered 2D materials, on standard polished oxide substrates, result in a nearly constant frictional, adhesive, and elastic response as the tip slides over the surface, making …
Overview Of The Kentucky Geological Survey No. 1 Hanson Aggregates Well, Carter County, Kentucky, J. Richard Bowersox, Stephen F. Greb, David C. Harris
Overview Of The Kentucky Geological Survey No. 1 Hanson Aggregates Well, Carter County, Kentucky, J. Richard Bowersox, Stephen F. Greb, David C. Harris
Information Circular--KGS
The Kentucky Geological Survey drilled the No. 1 Hanson Aggregates well in northern Carter County, Ky., to assess the carbon dioxide storage capacity and confining intervals in the Middle Cambrian–Upper Ordovician section in the southern Appalachian Basin, north of the Rome Trough. The well was drilled to a total depth of 4,835 ft, penetrating the Mississippian–Middle Cambrian Paleozoic section and 120 ft of Neoproterozoic Grenville granite gneiss. Steel casing was cemented to the surface at 350 ft and 2,944 ft to isolate the deep wellbore from the near-surface aquifer and provide anchors for pressure-control equipment. Eight cores totaling 453 ft …
Proton Mass Decomposition From The Qcd Energy Momentum Tensor, Yi-Bo Yang, Jian Liang, Yu-Jiang Bi, Ying Chen, Terrence Draper, Keh-Fei Liu, Zhaofeng Liu
Proton Mass Decomposition From The Qcd Energy Momentum Tensor, Yi-Bo Yang, Jian Liang, Yu-Jiang Bi, Ying Chen, Terrence Draper, Keh-Fei Liu, Zhaofeng Liu
Physics and Astronomy Faculty Publications
We report results on the proton mass decomposition and also on related quark and glue momentum fractions. The results are based on overlap valence fermions on four ensembles of Nf = 2 + 1 domain wall fermion configurations with three lattice spacings and three volumes, and several pion masses including the physical pion mass. With fully nonperturbative renormalization (and universal normalization on both quark and gluon), we find that the quark energy and glue field energy contribute 32(4)(4)% and 36(5)(4)% respectively in the MS¯ (modified minimal substraction) scheme at μ = 2 GeV. A quarter of the trace anomaly …
X-Search: An Open Access Interface For Cross-Cohort Exploration Of The National Sleep Research Resource, Licong Cui, Ningzhou Zeng, Matthew Kim, Remo Mueller, Emily Ruth Hankosky, Susan Redline, Guo-Qiang Zhang
X-Search: An Open Access Interface For Cross-Cohort Exploration Of The National Sleep Research Resource, Licong Cui, Ningzhou Zeng, Matthew Kim, Remo Mueller, Emily Ruth Hankosky, Susan Redline, Guo-Qiang Zhang
Computer Science Faculty Publications
Background: The National Sleep Research Resource (NSRR) is a large-scale, openly shared, data repository of de-identified, highly curated clinical sleep data from multiple NIH-funded epidemiological studies. Although many data repositories allow users to browse their content, few support fine-grained, cross-cohort query and exploration at study-subject level. We introduce a cross-cohort query and exploration system, called X-search, to enable researchers to query patient cohort counts across a growing number of completed, NIH-funded studies in NSRR and explore the feasibility or likelihood of reusing the data for research studies.
Methods: X-search has been designed as a general framework with two loosely-coupled components: …