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University of Kentucky Doctoral Dissertations
Alzheimer's disease (AD)|amyloid beta (Aâ)|preclinical Alzheimer's disease (PCAD)|zinc (Zn)|zinc transporter (ZnT)
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Alterations Of Zinc Transporters In Alzheimer's Disease, Ganna Lyubartseva
Alterations Of Zinc Transporters In Alzheimer's Disease, Ganna Lyubartseva
University of Kentucky Doctoral Dissertations
Alzheimer’s disease (AD), one of the major causes of disability and mortality in Western societies, is a progressive age-related neurodegenerative disorder. Increasing evidence suggests the etiology of AD may involve disruptions of zinc (Zn) homeostasis. We hypothesize that disruption of Zn homeostasis leads to alterations of Zn transporter (ZnT) proteins, resulting in increased production of neurotoxic amyloid beta (Aβ) peptide in AD brain. To address this hypothesis we carried out the following studies.
1. We characterized alterations of ZnT-1, ZnT-4 and ZnT-6 in the brain of preclinical AD (PCAD) subjects, who show no overt clinical manifestations of AD but demonstrate …