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Full-Text Articles in Physical Sciences and Mathematics
Diagnostics Of Dementia From Structural And Functional Markers Of Brain Atrophy With Machine Learning, Tetiana Habuza
Diagnostics Of Dementia From Structural And Functional Markers Of Brain Atrophy With Machine Learning, Tetiana Habuza
Dissertations
Dementia is a condition in which higher mental functions are disrupted. It currently affects an estimated 57 million people throughout the world. A dementia diagnosis is difficult since neither anatomical indicators nor functional testing is currently sufficiently sensitive or specific. There remains a long list of outstanding issues that must be addressed. First, multimodal diagnosis has yet to be introduced into the early stages of dementia screening. Second, there is no accurate instrument for predicting the progression of pre-dementia. Third, non-invasive testing cannot be used to provide differential diagnoses. By creating ML models of normal and accelerated brain aging, we …
The Design, Synthesis, And Characterization Of Copper-Based Metal-Organic Frameworks For Their Investigation Against Cancer And Their Effect As Anti-Microbial Agents, Sandy Elmehrath
Dissertations
A wide range of nanomaterials have been developed for biomedical applications, such as drug delivery, biomedical imaging, and sensors. Nanomaterials can include nanoparticles (NPs) and nanofibers with various dimensions that are both natural and synthetic. A successful nanomaterial, for use in biological applications, is characterized by its biocompatibility, biodegradability, intrinsic high surfaces area, high interconnected porosity, and functionality. These features were achieved with the development of metal-organic framework (MOF) nanostructures. MOFs are assemblies of metal ions and organic linkers that are built into different geometries and can exist in all dimensions (up to 3-D). The choice of linkers with well-defined …