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Full-Text Articles in Physical Sciences and Mathematics

Mining Biological Networks Towards Protein Complex Detection And Gene-Disease Association, Eileen Marie Hanna Sep 2015

Mining Biological Networks Towards Protein Complex Detection And Gene-Disease Association, Eileen Marie Hanna

Dissertations

Large amounts of biological data are continuously generated nowadays, thanks to the advancements of high-throughput experimental techniques. Mining valuable knowledge from such data still motivates the design of suitable computational methods, to complement the experimental work which is often bound by considerable time and cost requirements. Protein complexes or groups of interacting proteins, are key players in most cellular events. The identification of complexes not only allows to better understand normal biological processes but also to uncover Disease-triggering malfunctions. Ultimately, findings in this research branch can highly enhance the design of effective medical treatments. The aim of this research is …


Protein Domain Linker Prediction: A Direction For Detecting Protein-Protein Interactions, Maad Mohammad Hasan Shatnawi Jun 2015

Protein Domain Linker Prediction: A Direction For Detecting Protein-Protein Interactions, Maad Mohammad Hasan Shatnawi

Dissertations

Protein chains are generally long and consist of multiple domains. Domains are the basic elements of protein structures that can exist, evolve, and function independently. The accurate and reliable identification of protein domains and their interactions has very important impacts in several protein research areas. The accurate prediction of protein domains is a fundamental stage in both experimental and computational proteomics. The knowledge of domains is an initial stage of protein tertiary structure prediction which can give insight into the way in which proteins work. The knowledge of domains is also useful in classifying proteins, understanding their structures, functions and …


Scalable Multi-Hop Data Dissemination In Vehicular Ad Hoc Networks, Moumena Abdullah Chaqfeh May 2015

Scalable Multi-Hop Data Dissemination In Vehicular Ad Hoc Networks, Moumena Abdullah Chaqfeh

Dissertations

Vehicular Ad hoc Networks (VANETs) aim at improving road safety and travel comfort, by providing self-organizing environments to disseminate traffic data, without requiring fixed infrastructure or centralized administration. Since traffic data is of public interest and usually benefit a group of users rather than a specific individual, it is more appropriate to rely on broadcasting for data dissemination in VANETs. However, broadcasting under dense networks suffers from high percentage of data redundancy that wastes the limited radio channel bandwidth. Moreover, packet collisions may lead to the broadcast storm problem when large number of vehicles in the same vicinity rebroadcast nearly …