Physical Sciences and Mathematics Commons^™

A Study Of Information Bots And Knowledge Bots, Amartya Hatua

Dissertations

In this dissertation, a study of different aspects of information bots and knowledge bots is done. The research contributes to a better understanding of the various characteristics of information bots as well as the different patterns and factors responsible for the information diffusion in a social network. This research also shows how these factors can be used to predict information diffusion for a particular topic in a social network. The second part of the research is focused on strategies for improving the knowledge base of knowledge bots, where two different approaches are studied. In the first approach, knowledge is transferred …

Machine Learning Approaches For Improving Prediction Performance Of Structure-Activity Relationship Models, Gabriel Idakwo

Dissertations

In silico bioactivity prediction studies are designed to complement in vivo and in vitro efforts to assess the activity and properties of small molecules. In silico methods such as Quantitative Structure-Activity/Property Relationship (QSAR) are used to correlate the structure of a molecule to its biological property in drug design and toxicological studies. In this body of work, I started with two in-depth reviews into the application of machine learning based approaches and feature reduction methods to QSAR, and then investigated solutions to three common challenges faced in machine learning based QSAR studies.

First, to improve the prediction accuracy of learning …