Open Access. Powered by Scholars. Published by Universities.®
Physical Sciences and Mathematics Commons™
Open Access. Powered by Scholars. Published by Universities.®
- Discipline
Articles 1 - 2 of 2
Full-Text Articles in Physical Sciences and Mathematics
Interactions Of Zn2+ On Insulin Oligomer Formation, Stability, And Fragmentation: Analysis Using Esi-Im-Ms, Tiffany Culver
Interactions Of Zn2+ On Insulin Oligomer Formation, Stability, And Fragmentation: Analysis Using Esi-Im-Ms, Tiffany Culver
Honors Theses
Insulin is a hormone protein essential to the regulation of blood sugar levels. Although it is active as a hormone in the monomer (single insulin unit) form, it is stored in the pancreas as a hexamer – a coordination of six insulin units and zinc ions. This research analyzes the effects of zinc ions on the formation, stability, and fragmentation of the hexamer and other oligomer species in varying solution and instrument conditions, including the ability of the higher oligomers to transfer from crystallization to solution to a gas phase for analysis using electrospray ionization ion mobility mass spectrometry (ESI-IM-MS). …
Interstellar Navigation By Pulsars, Andrew Dahir