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Full-Text Articles in Physical Sciences and Mathematics
Synthesis Of New Antimicrobial Agents; Amide Derivatives Of Pyranones And Pyridinones, Mutlu Di̇lsi̇z Aytemi̇r, Robert C. Hider, Di̇lek Demi̇r Erol, Meral Özalp, Meli̇ke Eki̇zoğlu
Synthesis Of New Antimicrobial Agents; Amide Derivatives Of Pyranones And Pyridinones, Mutlu Di̇lsi̇z Aytemi̇r, Robert C. Hider, Di̇lek Demi̇r Erol, Meral Özalp, Meli̇ke Eki̇zoğlu
Turkish Journal of Chemistry
In this study, 4(1H)-pyridinones with an amide function in Position 2 of the pyridinone ring showed antimicrobial activity. The synthesis and the biological properties of some novel amide derivatives of pyran-4(1H)-one and 4(1H)-pyridinone have been reported. Amide derivatives of pyran-4(1H)-one and 4(1H)-pyridinone were prepared using two different methods. Antimicrobial activities were determined as MIC values using the microdilution broth method against the bacteria Staphylococcus aureus, Enterococcus faecalis, Escherichia coli and Pseudomonas aeruginosa and the fungi Candida albicans, Candida krusei and Candida parapsilosis. Compounds 6 and 9 exhibited the best inhibitor activity against S. aureus.
Synthesis And Evaluation Of Antimicrobial Activity Of New 3-Hydroxy-6-Methyl-4-Oxo-4h-Pyran-2- Carboxamide Derivatives, Mutlu Di̇lsi̇z Aytemi̇r, Di̇lek Demi̇r Erol, Robert Charles Hider, Meral Özalp
Synthesis And Evaluation Of Antimicrobial Activity Of New 3-Hydroxy-6-Methyl-4-Oxo-4h-Pyran-2- Carboxamide Derivatives, Mutlu Di̇lsi̇z Aytemi̇r, Di̇lek Demi̇r Erol, Robert Charles Hider, Meral Özalp
Turkish Journal of Chemistry
The synthesis of a range of 3-hydroxy-4-oxo-4H-pyran-2- carboxamide with antimicrobial activity is described. Amide derivatives of pyranone were synthesised using TBTU [2-(1H-benzotriazol-1-yl)-1,1,3,3-tetramethyluronium tetrafluoroborate] as a coupling agent and NMM (N-methylmorpholine) as a base. Antimicrobial activities were determined as MIC values using the microdilution broth method against Staphylococcus aureus, Entrococcus faecalis, Escherichia coli and Pseudomonas aeruginosa for bacteria and Candida albicans, C. krusei and C. parapsilosis for fungi. 3-Hydroxy-6-methyl-4-oxo-4H-pyran-2-[N-(4'-methylcoumarin-7-yl) carboxamide] (8c) exhibited higher antibacterial activity against S. aureus, E. faecalis and E. coli than the other compounds. In addition, 8c was more active against C. krusei than the other synthesised compounds.