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Full-Text Articles in Physical Sciences and Mathematics
Synthesis Of $E$-Stilbene Azomethines As Potent Antimicrobial And Antioxidant Agents, Ahsan Iqbal, Zulfiqar Ali Khan, Sohail Anjum Shahzad, Muhammad Usman, Shakeel Ahmad Khan, Abdul H. Fauq, Ayesha Bari, Muhammad Aamir Sajid
Synthesis Of $E$-Stilbene Azomethines As Potent Antimicrobial And Antioxidant Agents, Ahsan Iqbal, Zulfiqar Ali Khan, Sohail Anjum Shahzad, Muhammad Usman, Shakeel Ahmad Khan, Abdul H. Fauq, Ayesha Bari, Muhammad Aamir Sajid
Turkish Journal of Chemistry
A series of new extensively conjugated $E$-stilbene azomethines (5a-5h) were synthesized and screened for their antioxidant and antimicrobial activity. The compounds were tested against bacterial (Escherichia coli, Staphylococcus aureus, Klebsiella pneumoniae, and Bacillus subtilis) and fungal strains (Aspergillus niger, A. flavus, and Trichoderma harzianum) using the agar well diffusion method. Among the tested compounds, $N$'-(4-nitrobenzylidene)-2-(($E)$-styryl)benzohydrazide (5g) was found to possess potent antimicrobial activity higher than some drugs with significant activity reported in the literature, e.g., cefradine and terbinafine hydrochloride. Additionally, compounds 5a-5h were also evaluated for antioxidant potential using DPPH free radical scavenging and ferric thiocyanate (FTC) assays. Among these, …