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Full-Text Articles in Physical Sciences and Mathematics
Calixcephems: Clustered Cephalosporins Analogous To Calixpenams As Novel Potential Anti-Mrsa Agents, Fazel Nasuhi Pur, Karim Akbari Dilmaghani
Calixcephems: Clustered Cephalosporins Analogous To Calixpenams As Novel Potential Anti-Mrsa Agents, Fazel Nasuhi Pur, Karim Akbari Dilmaghani
Turkish Journal of Chemistry
Two novel clusters of cephalosporin based on calixarene were synthesized directly or by ring expansion of the penicillin arms of calixpenams to the corresponding cephem arms via sulfoxide intermediates. Antibiotic tests showed that calixcephems have a noteworthy increase in antibacterial activity against methicillin-resistant strains of Staphylococcus aureus (MRSA) with respect to parent calixpenams and their corresponding single cephems.
Calixpenams: Synthesis, Characterization, And Biological Evaluation Of Penicillins V And X Clustered By Calixarene Scaffold, Fazel Nasuhi Pur, Karim Akbari Dilmaghani
Calixpenams: Synthesis, Characterization, And Biological Evaluation Of Penicillins V And X Clustered By Calixarene Scaffold, Fazel Nasuhi Pur, Karim Akbari Dilmaghani
Turkish Journal of Chemistry
Four 6-aminopenicillanic acid moieties were grafted at either rim of calix[4]arene, giving 2 novel generations of penicillin, which were named calixpenam. Antibiotic tests showed that they have amplified activity with respect to the corresponding penams against 3 gram-positive nonpenicillinase-producing strains of Streptococcus.