Physical Sciences and Mathematics Commons^™

Cenozoic Extension Of The Lake Tanganyika Rift, East Africa: Structures, Tectonostratigraphy And Paleoenvironmental Reconstruction, Shaidu Shaban

Dissertations - ALL

Active continental rifts are ideal sites for understanding the break-up of continents, and long-lived rift lake environments are known as important reservoirs for endemic communities and biodiversity. The sedimentary fill of extensional continental rifts within the East Africa Rift System (EARS) records a long history of continental extension and variable tropical climate that is unparalleled in its duration and fidelity. Continental extensional basins are sensitive to variations caused by the interplay between tectonics, sedimentary processes, and climate change. However, to discern the sedimentary fill history and its related tectonostratigraphy, as well as for reconstructing past climate changes, high-fidelity data such …

Interpretable Network Representations, Shengmin Jin

Dissertations - ALL

Networks (or interchangeably graphs) have been ubiquitous across the globe and within science and engineering: social networks, collaboration networks, protein-protein interaction networks, infrastructure networks, among many others. Machine learning on graphs, especially network representation learning, has shown remarkable performance in network-based applications, such as node/graph classification, graph clustering, and link prediction. Like performance, it is equally crucial for individuals to understand the behavior of machine learning models and be able to explain how these models arrive at a certain decision. Such needs have motivated many studies on interpretability in machine learning. For example, for social network analysis, we may need …

Observation Of The Ξ_B^-→Λ_B^0 Π^- Decay And Measurement Of B(Ξ_B^-→Λ_B^0 Π^-), Zhuoming Li

Dissertations - ALL

We present the first observation of the weak decay Ξ−b → Λ0b π−, which is mediated by an s → u ̄ud transitionwithin the Ξ_b^- baryon. The analysis uses a pp collision data sample at a center-of-mass energy of 13 TeV corresponding to 5.5 fb^(−1) of integrated luminosity. The sample of Λb0 baryons used in this analysis are reconstructed through their decays to Λ+c π− and Λ+c π−π+π−. From a fit to the Ξ−b → Λ0b π− mass spectrum, the Ξ−b → Λ0b π− decay is observed with a significance of 11.3 standard deviations, thus establishing observation of this decay. …

Testing Detrital Zircon Age Bias In Tectonic Provenance: Examples From Modern Alluvium In The South Island, New Zealand, Will Sparhawk Fisher

Theses - ALL

Detrital zircon (DZ) grains from 13 drainages across the South Island, New Zealand, were U-Pb dated to ascertain how accurately their ages reflect the geologic record of exposed bedrock. With the proliferation of inexpensive and easily accessible ion microprobes and laser ablation inductively coupled plasma mass spectrometers, DZ dating has become the dominant chronometer for elucidating tectonic systematics. Zircon’s physical and chemical resilience makes it an ideal candidate for U-Pb geochronometry, but is also a potential source of bias. Zircon’s resilience in sedimentary systems means it rarely occurs as first order detritus. N = 966 zircon grains from Modern alluvium …

Heterogeneous Strain Distribution & The Effects Of High Frequency Climate Change On The Evolution Of Early-Stage Rift Systems: Case Studies From Lakes Tanganyika And Malawi (Nyasa), East Africa, Lachlan Wright

Dissertations - ALL

The break-up of the earth’s crust through the formation of continental rift basins is a fundamental aspect of plate-tectonics and the first step that ultimately leads to plate-spreading, new continent formation, and the creation of ocean basins. Within continental rifts, processes associated with extensional faulting drive uplift and subsidence of the landscapes forming rift valleys, and climatically influenced processes act upon these transient landscapes, erode them, modify relief, and produce sediments that infill the rift valleys creating the stratigraphic record. Continental rifts are highly sensitive to the interplay between extensional faulting, sedimentary processes, and climate change, and variations in the …

Extracellular Vimentin Is Sufficient To Promote Cell Attachment, Spreading, And Motility By A Mechanism Involving N-Acetyl Glucosamine-Containing Structures, Robert Bucki, Daniel V. Iwamoto, Xuechen Shi, Katherine E. Kerr, Fitzroy J. Byfield, Lukasz Suprewicz, Karol Sklodowski, Julian Sutaria, Pawel Misiak, Agnieszka Z. Wilczewska, Sekar Ramachandran, Aaron Wolfe, Minh H. Thanh, Eli Whalen, Alison E. Patteson, Paul A. Janmey

Physics - All Scholarship

Vimentin intermediate !laments form part of the cytoskeleton

of mesenchymal cells, but under pathological conditions often

associatedwith in"ammation, vimentin !laments depolymerize as

the result of phosphorylation or citrullination, and vimentin

oligomers are secreted or released into the extracellular environment.

In the extracellular space, vimentin can bind surfaces of cells

and the extracellular matrix, and the interaction between extracellular

vimentin and cells can trigger changes in cellular functions,

such as activation of !broblasts to a !brotic phenotype. The

mechanism by which extracellular vimentin binds external cell

membranes and whether vimentin alone can act as an adhesive

anchor for cells is largely …

Algorithmic Solutions To Combat Online Fake News, Xinyi Zhou

Dissertations - ALL

The unprecedented growth of new information producing, distributing, and consuming every moment on the Web has fostered the rise of ``fake news.'' Because of its detrimental effect on democracy, global economies, and public health, effectively combating online fake news has become an essential and urgent task.

This dissertation starts with making typological, theoretical, and empirical efforts to promote the public's comprehension of fake news and lay the foundation for algorithmically combating fake news. As there has been no universal definition of fake news, this dissertation discusses the definition of fake news from three dimensions: veracity, intention, and news, comparing it …

The Design, Synthesis, And Investigation Into Small Molecule Modulators Of The Src Homology 2 Domain-Containing Inositol 5’-Phosphatase (Ship), Shea Thomas Meyer

Dissertations - ALL

The PI3K pathway is a major cell signaling pathway that influences survival and longevity in eukaryotic cells. Abnormal signaling of this pathway has been implicated in a number of disorders, including Alzheimer's disease and cancer. The PI3K pathway utilizes the inositolphospholipid PI(3,4,5)P3 as a key secondary messenger in the transmission of signals from outside the cell to the nucleus. The SRC Homology 2 containing Inositol 5’-Phosphatase (SHIP) also plays a key role in the PI3K pathway, mediating hydrolysis of the inositol phospholipid PI(3,4,5)P3 to PI(3,4)P2. Early testing has shown modulation of SHIP activity through the use of small molecule modulators …

High Fidelity Universal Gates Performed On A Continuously-Decoupled Coherence Enhanced Transmon Qubit, Michael Senatore

Dissertations - ALL

Decoherence is the primary limiting factor for the utility of modern qubits and qubit networks; most chiefly, pure dephasing which limits the operational time any gate-sequence can produce a high-fidelity result. In this dissertation, I present the results of my experiment, performing fast, high fidelity, universal single-qubit gates, on a qubit which has been decoupled from pure dephasing resulting from environmental noise. This technique can expand operational ranges of qubits–such as allowing the high-coherence operation of a flux-tunable qubit far away from its flux-insensitive sweet-spot; broadening our selection of viable qubits by making otherwise low-coherence qubits operable with high coherence, …

A Torsion-Based Rheometer For Measuring Viscoelastic Material Properties, Merrill E. Asp, Elise Jutzeler, Jakub Kochanowski, Katherine Kerr, Dawei Song, Sarthak Gupta, Robert Carroll, Alison E. Patteson

Physics - All Scholarship

Rheology and the study of viscoelastic materials are an integral

part of engineering and the study of biophysical systems. Tissue rheology is even

used in the study of cancer and other diseases. However, the cost of a rheometer is

feasible only for colleges, universities, and research laboratories. Even if a rheometer

can be purchased, it is bulky and delicately calibrated, limiting its usefulness to the

laboratory itself. The design presented here is less than a tenth of the cost of a

professional rheometer. The design is also portable, making it the ideal solution to

introduce viscoelasticity to high school students …

Exploring The Biomedical Applications Of Polyurethane-Based Foams, Films, And Hydrogels, Anand Utpal Vakil

Dissertations - ALL

Shape memory polymers (SMPs) are a class of smart materials that can be temporarily stored in a deformed shape and can actively recover their original shape upon exposure to an external stimulus, such as heat, magnetic field, moisture, pH, light, or electric field. The ability of SMPs to change shape when required can be used for a wide range of applications, especially in the case of minimally invasive biomedical applications. In this work, polyurethane-based SMPs were explored for their use in tissue engineering, drug delivery, and wound healing applications.

In the second chapter, low density porous foams with tunable degradability …

Design And Modeling Of Superconducting Hardware For Implementing Quantum Stabilizers, Yebin Liu

Dissertations - ALL

Superconducting qubits are one of the leading systems for implementing quantum processors. Realizing fault-tolerant quantum computation requires some form of quantum error correction, which typically involves performing repeated stabilizer operations on groups of physical qubits in an array to form a logical qubit with enhanced protection against errors. Realizing a logical qubit that is suitable for running quantum algorithms requires an array with a significant number of physical qubits, which is extremely challenging. However, the physical qubit overhead can be reduced by lowering the error rate on the physical qubits. Current state-of-the-art superconducting qubit designs do not have robust protection …

Dynamic Remodeling Of Fiber Networks With Stiff Inclusions Under Compressive Loading, Robert J. Carroll, Minh H. Thanh, Alison E. Patteson

Physics - All Scholarship

The ability of tissues to sustain and withstand mechanical stress is critical to tissue development and healthy tissue maintenance. The mechanical properties of tissues are typically considered to be dominated by the fibrous extracellular matrix (ECM) component of tissues. Fiber network mechanics can capture certain mechanical features of tissues, such as shear strain stiffening, but is insufficient in describing the compressive response of certain tissues and blood clots that are rich in extracellular matrix. To understand the mechanical response of tissues, we employ a contemporary mechanical model, a fibrous network of fibrin embedded with inert bead inclusions that preserve the …

Characterization Of Superconducting Hardware For Implementing Quantum Stabilizers, Kenneth Richard Dodge

Dissertations - ALL

Superconducting qubits are one of the leading approaches being investigated for building a scalable quantum computer. In the presence of external noise and perturbations plus local microscopic fluctuations and dissipation in the qubit environment, arbitrary quantum states will decohere, leading to bit-flip and phase-flip errors of the qubit. In order to build a fault-tolerant quantum computer that can preserve and process quantum information in the presence of noise and dissipation, one must implement some form of quantum error correction. Stabilizer operations are at the heart of quantum error correction and are typically implemented in software-controlled entangling gates and measurements of …

Search For Numi Mudar Electron Neutrinos In Microboone, Ohana Benevides Rodrigues

Dissertations - ALL

Muon Decay-at-Rest (μDAR) produces electron-neutrinos (νe) in the 0 to 53 MeV energy range. The given range is especially interesting for its similarity to Supernovae-produced νe. The Deep Underground Neutrino Experiment (DUNE) has as one of its main goals to measure Supernovae neutrinos on the occasion of a Galactic Supernova burst. To optimize the chances of detection, a low-energy neutrino-LAr cross-section (XS) measurement is a piece of important information to have at hand. MicroBooNE presents a good opportunity to explore the low-energy ν-LAr detection and XS using the μDAR neutrinos and therefore develop the tools necessary for DUNE to interpret …

Measurements Of B → D(∗)−,0d(∗)+,0k+Π− Branching Fractions In The K∗0 Mass Window, Harris Bernstein

Dissertations - ALL

This thesis presents measurements of 11 branching fractions of the form B →D(∗)−,0D(∗)+,0K+π− within the K∗0 mass window using LHCb data taken in 2016, 2017 and 2018. All 11 branching fractions are measured simultaneously and are reported alongside the covariance and correlation matrices for the final measurement.

How Green Lakes State Park Got Its Name: The Optics And Appearance Of Fayetteville Green Lakes, Eric A. Schiff

Physics - All Scholarship

The extraordinary and variable appearance of the Fayetteville Green Lakes in the spring, summer, and fall has been the subject of journalistic and scientific attention for more than 150 years. This article addresses the subject in two sections for differing readerships. The first section is a description of the essential science for a general readership. The second section is an abstract of the science for technically knowledgeable readers. The layout of the article is designed for a folded paper flier suitable for distribution to visitors to the lakes.

The article describes the three key properties of the lakes’ waters that …

Mechanologic: Designing Mechanical Devices That Compute, Michelle Berry

Dissertations - ALL

Despite their initial success and impact on the development of the modern computer, mechanical computers were quickly replaced once electronic computers became viable. Recently, there has been increased interest in designing devices that compute using modern and unconventional materials. In this dissertation, we investigate multiple ways to realize a mechanical device that can compute, with a main focus on designing mechanical equivalents for wires and transistors. For our first approach at designing mechanical wires, we present results on the propagation of signals in a soft mechanical wire composed of bistable elements. When we send a signal along bistable wires that …

Protection Against Contagion In Complex Networks, Pegah Hozhabrierdi

Dissertations - ALL

In real-world complex networks, harmful spreads, commonly known as contagions, are common and can potentially lead to catastrophic events if uncontrolled. Some examples include pandemics, network attacks on crucial infrastructure systems, and the propagation of misinformation or radical ideas. Thus, it is critical to study the protective measures that inhibit or eliminate contagion in these networks. This is known as the network protection problem.

The network protection problem investigates the most efficient graph manipulations (e.g., node and/or edge removal or addition) to protect a certain set of nodes known as critical nodes. There are two types of critical nodes: (1) …

Distortion Estimates For Conformal Maps Predicated On Geometric Properties Of A Domain, Christopher G. Donohue

Dissertations - ALL

Geometric properties of a domain in the complex plane reflect important informationabout the conformal maps to and from the domain. We examine a variety of geometric properties and use them to construct explicit global distortion bounds for both the compression and stretching of conformal map. Compressive distortion is controlled when the modulus of the derivative of a complex function is bounded from below, expansive distortion when it is bounded above. For the initial set of results, we quantify the degree to which a convex domain is nearly round with two parameters; radii of the largest inscribed disk and smallest circumscribed …

Investigation Of Holographic Lattice Theories, Muhammad Asaduzzaman

Dissertations - ALL

The Anti-de Sitter/Conformal Field theory (AdS/CFT) correspondence, also known as holography, has been the focus of a great deal of interest and research for the last two decades. It has improved our understanding of general relativity and quantum field theories simultaneously through the interplay between these two different kinds of theories. However, there are still many aspects of holography that we do not understand or demand further analysis. Perturbative quantum field theory and perturbative metric expansion techniques are not equipped to investigate holography in some of the most interesting regimes such as the strongly interacting gravitational theory in anti-de Sitter …

Design Of Novel Metalloenzymes And Investigation Of Protein-Metal Interactions, Alona Kulesha

Dissertations - ALL

Metalloproteins are the proteins that utilize metals or metal complexes as cofactors and exhibit a wide range of functions from oxygen transport and regulation of transcription to hydroxylation of alkanes and water splitting, even though they employ a limited set of metals and metal-binding ligands. The investigation of metalloprotein amino acid sequence, structure and function relationships can uncover the principles behind natural metalloprotein design and opens the possibility of their implication as scaffolds for the design of novel catalysts and biomaterials. Protein engineering is a set of techniques that allows to install new functionalities into existing proteins or to design …

Geometry Of Discrete And Continuous Bounded Surfaces, Kyung Eun Kim

Dissertations - ALL

We work on reconstructing discrete and continuous surfaces with boundaries using length constraints. First, for a bounded discrete surface, we discuss the rigidity and number of embeddings in three-dimensional space, modulo rigid transformations, for given real edge lengths. Our work mainly considers the maximal number of embeddings of rigid graphs in three-dimensional space for specific geometries (annulus, strip). We modify a commonly used semi-algebraic, geometrical formulation using Bézout's theorem, from Euclidean distances corresponding to edge lengths. We suggest a simple way to construct a rigid graph having a finite upper bound. We also implement a generalization of counting embeddings for …

Measurement Of |Vcb| Using The Semileptonic Decay Λb → Λcμνμ, Scott Edward Ely

Dissertations - ALL

A preliminary measurement of the quark-mixing parameter |Vcb| using the exclusive decay Λ0b→ Λ+c μ−νμ is presented. A sample of Λb semileptonic decays is provided by √s = 13TeV proton-proton collisions collected by the LHCb detector in 2017. Λ0b → Λ+c μ−νμX decays are identified from muon tracks, combined with a Λc baryon. The ground state Λ0b → Λ+c μ−νμ is isolated by a fit to the Λb corrected mass spectrum. The raw yield NRaw(Λ0b → Λ+c μ−νμ) is corrected, and the semileptonic width ΓMeas. (Λ0b → Λ+c μ−νμ) is obtained. Lattice QCD calculations predict ΓTh.(Λ0b → Λ+c μ−νμ)/|Vcb|2. A …

A New Class Of Antibiotic That Prevents Drug Tolerance, Persistence, And Resistance By Controlling Emergence Of Phenotypes., Pankaj Dinkar Patil

Dissertations - ALL

The fight against bacterial infections and innovations in antibiotic therapy has never halted throughout human history. However, bacteria have evolved smartly and resistance against practically all conventional antibiotics has been developed. Furthermore, bacteria can form biofilms, which are surface-attached multicellular colonies. Biofilms shield bacteria against antibiotics and makes it harder to entirely eradicate infections . Under antibiotics stress, bacteria evolve into different phenotypes like hyper motile, hyper adherent and hyper virulent which are tolerant and persistent to antibiotic treatment. The use of antibiotic therapy to combat such resilient bacterial phenotypes is extremely tough. As a result, the scientific community is …

Patterns Of Dissolved Methane In Groundwater And Its Contribution To Emissions Inventories, Amanda E. Campbell

Dissertations - ALL

The Marcellus Shale is the largest shale gas play in the U.S. production of natural gas using high-volume hydraulic fracturing (HVHF) and production is prevalent throughout the play except in New York (NY), where it is currently banned. High concentrations of methane, the main component of natural gas, in groundwater, as well as its presence in the atmosphere, can have negative consequences. In this dissertation, three aspects of this issue are explored: 1) how and why naturally-occurring methane concentrations vary through time; 2) how elevated naturally-occurring methane concentrations in domestic water wells can be predicted from commonly observed well characteristics; …

Assessing Impact Of Unconventional Oil And Gas Development On Groundwater Quality In The Northern Appalachian Region With Mixed Land Uses, Favour C. Epuna

Theses - ALL

Over the past decade, the rapid growth of unconventional oil and gas development (UOGD) has raised public concerns about its potential impact on groundwater quality. High methane and salt levels in groundwater have been the most widely cited UOGD-related impairments. The attribution of these contaminants to UOGD is usually complex, especially in regions with mixed land uses. Here, we compiled a large hydrogeochemistry dataset containing 13 geochemical analytes for 17,794 groundwater samples from the rural northern Appalachia, i.e., 19 counties located on the boundary between Pennsylvania (PA; UOGD is permitted) and New York (NY; UOGD is banned). With this dataset, …

A Gis Suitability Model Evaluating Habitat Characteristics Influencing Beaver (Castor Canadensis) Lodge Site Selection And Lodge Occupancy In Central Adirondacks, New York, Amanda K. Jacobs

Theses - ALL

The North American beaver (Castor canadensis) represents a quintessential example of an "ecosystem engineer." Yet the species' landscape-scale impacts on hydrology, geomorphology, and ecosystem ecology are not uniformly distributed through landscapes or time. Understanding beaver lodge site selection and lodge fidelity through time can help to predict where the greatest effects of beaver activity may occur. In this research project, I seek to understand the relationships between beaver habitat suitability, the habitat variables that currently define suitable areas, and lodge occupancy over time. Using Geographic Information Systems (GIS) to model habitat suitability, I use hydrologic, vegetative, and physiographic variables to …

Studying Redox Conditions Of Devonian And Neoproterozoic Oceans Using I/Ca Proxy From Bulk Carbonate Rocks, Ruliang He

Dissertations - ALL

Iodine is an important trace element in biogeochemical and redox reactions. It has a nearly consistent concentration of ~0.46 μmol/L in the seawater and the inorganic speciation (IO3− and I−) of iodine is primarily controlled by redox conditions in water columns. Iodate (IO3−), not iodide (I−), is the only species that can be incorporated into carbonate minerals. Therefore, I/Ca ratio from carbonate rocks can be used to constrain the redox condition in the water column over a range of time scale. This dissertation contains three chapters that utilizes I/Ca ratio from bulk carbonate rocks to reconstruct ocean redox changes during …

Adversarial Activity Detection And Prediction Using Behavioral Biometrics, Amin Fallahi

Dissertations - ALL

Behavioral biometrics can be used in different security applications like authentication, identification, etc. One of the trending applications is predicting future activities of people and guessing whether they will engage in malicious activities in the future. In this research, we study the possibility of predicting future activities and propose novel methods for near-future activity prediction.

First, we study gait signals captured using smartphone accelerometer sensor and build a model to predict a future gait signal. Activity recognition using body movements captured from mobile phone sensors has been a major point of interest in recent research. Data that is being continuously …