Physical Sciences and Mathematics Commons^™

Determination Of Dimethyl Trisulfide In Rabbit Blood Using Stir Bar Sorptive Extraction Gas Chromatography-Mass Spectrometry, Erica Mananadhar, Nujud Maslamani, Ilona Petrikovics, Gary A. Rockwood, Brian A. Logue

Chemistry and Biochemistry Faculty Publications

Cyanide poisoning by accidental or intentional exposure poses a severe health risk. The current Food and Drug Administration approved antidotes for cyanide poisoning can be effective, but each suffers from specific major limitations concerning large effective dosage, delayed onset of action, or dependence on enzymes generally confined to specific organs. Dimethyl trisulfide (DMTS), a sulfur donor that detoxifies cyanide by converting it into thiocyanate (a relatively nontoxic cyanide metabolite), is a promising next generation cyanide antidote. Although a validated analytical method to analyze DMTS from any matrix is not currently available, one will be vital for the approval of DMTS …