Physical Sciences and Mathematics Commons^™

Parametric And Nonparametric Methods For Understanding The Relationship Between Carcinogen-Induced Dna Adduct Levels In Distal And Proximal Regions Of The Colon., Jeffrey S. Morris, Naisyin Wang, Joanne R. Lupton, Robert S. Chapkin, Nancy D. Turner, Mee-Young Hong, Raymond J. Carroll

Jeffrey S. Morris

An important problem in studying the etiology of colon cancer is understanding the relationship between DNA adduct levels (broadly, DNA damage) in cells within colonic crypts in distal and proximal parts of the colon, following treatment with a carcinogen and different types of diet. In particular, it is important to understand whether rats who have elevated adduct levels in particular positions in distal region crypts also have elevated levels in the same positions of the crypts in proximal regions, and whether this relationship depends on diet. We cast this problem as estimating the correlation function of two responses as a …