Open Access. Powered by Scholars. Published by Universities.®
Physical Sciences and Mathematics Commons™
Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 2 of 2
Full-Text Articles in Physical Sciences and Mathematics
Nonlinear Dynamical Systems Of Fed-Batch Fermentation And Their Optimal Control, Chongyang Liu, Zhaohua Gong, Enmin Feng, Hongchao Yin
Nonlinear Dynamical Systems Of Fed-Batch Fermentation And Their Optimal Control, Chongyang Liu, Zhaohua Gong, Enmin Feng, Hongchao Yin
Chongyang Liu
In this article, we propose a controlled nonlinear dynamical system with variable switching instants, in which the feeding rate of glycerol is regarded as the control function and the moments between the batch and feeding processes as switching instants, to formulate the fed-batch fermentation of glycerol bioconversion to 1,3-propanediol (1,3-PD). Some important properties of the proposed system and its solution are then discussed. Taking the concentration of 1,3-PD at the terminal time as the cost functional, we establish an optimal control model involving the controlled nonlinear dynamical system and subject to continuous state inequality constraints. The existence of the optimal …
Identification Of Intracellular Kinetic Parameters In Continuous Bioconversion Of Glycerol By Klebsiella Pneumoniae, Enmin Feng, Chongyang Liu, Zhaohua Gong, Yaqin Sun
Identification Of Intracellular Kinetic Parameters In Continuous Bioconversion Of Glycerol By Klebsiella Pneumoniae, Enmin Feng, Chongyang Liu, Zhaohua Gong, Yaqin Sun
Chongyang Liu
In this paper, we propose a hybrid nonlinear dynamical system to describe the concentration changes of extracellular and intracellular substances of glycerol bioconversion to 1,3- propanedol (1,3-PD) in microbial continuous cultures. It is proved that the solution to the system exists and is continuous with respect to kinetic parameters. Subsequently, a novel quantitative definition of biological robustness is investigated. We present a performance index based on experiment data of extracellular concentrations and biological robustness. Taking the proposed hybrid nonlinear dynamical system as a constraint, we establish an identification model to determine the most reasonable metabolic pathway and optimal kinetic parameters. …