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The Importance Of Solvent Effects On The Mechanism Of The Pfeiffer Effect, Jamie Lunkley, Ngoc Nguyen, Kristina Tuminaro, Dana Margittai, Gilles Muller
The Importance Of Solvent Effects On The Mechanism Of The Pfeiffer Effect, Jamie Lunkley, Ngoc Nguyen, Kristina Tuminaro, Dana Margittai, Gilles Muller
Faculty Publications, Chemistry
The Pfeiffer effect is observed when an optically active compound such as an amino acid is introduced to a solution containing a labile racemic metal complex, and an equilibrium shift is obtained. The “perturbation” results in an excess of one enantiomer over the other. The shift is a result of a preferential outer sphere interaction between the introduced chiral species and one enantiomeric form (Λ or ∆) of a labile metal complex. Speculations regarding the mechanism of the Pfeiffer effect have attributed observations to a singular factor such as pH, solvent polarity, or numerous other intermolecular interactions. Through the use …