Physical Sciences and Mathematics Commons^™

A Framework For The Statistical Analysis Of Mass Spectrometry Imaging Experiments, Kyle Bemis

Open Access Dissertations

Mass spectrometry (MS) imaging is a powerful investigation technique for a wide range of biological applications such as molecular histology of tissue, whole body sections, and bacterial films , and biomedical applications such as cancer diagnosis. MS imaging visualizes the spatial distribution of molecular ions in a sample by repeatedly collecting mass spectra across its surface, resulting in complex, high-dimensional imaging datasets. Two of the primary goals of statistical analysis of MS imaging experiments are classification (for supervised experiments), i.e. assigning pixels to pre-defined classes based on their spectral profiles, and segmentation (for unsupervised experiments), i.e. assigning pixels to newly …

Low Rank Methods For Optimizing Clustering, Yangyang Hou

Open Access Dissertations

Complex optimization models and problems in machine learning often have the majority of information in a low rank subspace. By careful exploitation of these low rank structures in clustering problems, we find new optimization approaches that reduce the memory and computational cost.

We discuss two cases where this arises. First, we consider the NEO-K-Means (Non-Exhaustive, Overlapping K-Means) objective as a way to address overlapping and outliers in an integrated fashion. Optimizing this discrete objective is NP-hard, and even though there is a convex relaxation of the objective, straightforward convex optimization approaches are too expensive for large datasets. We utilize low …

Differentially Private Data Publishing For Data Analysis, Dong Su

Open Access Dissertations

In the information age, vast amounts of sensitive personal information are collected by companies, institutions and governments. A key technological challenge is how to design mechanisms for effectively extracting knowledge from data while preserving the privacy of the individuals involved. In this dissertation, we address this challenge from the perspective of differentially private data publishing. Firstly, we propose PrivPfC, a differentially private method for releasing data for classification. The key idea underlying PrivPfC is to privately select, in a single step, a grid, which partitions the data domain into a number of cells. This selection is done using the exponential …