Physical Sciences and Mathematics Commons^™

Relative Sensitivities Of Dce-Mri Pharmacokinetic Parameters To Arterial Input Function (Aif) Scaling, Xin Li, Yu Cai, Brendan Moloney, Yiyi Chen, Wei Huang, Mark Woods, Fergus V. Coakley, William D. Rooney, Mark G. Garzotto, Charles S. Springer Jr.

Chemistry Faculty Publications and Presentations

Dynamic-Contrast-Enhanced Magnetic Resonance Imaging (DCE-MRI) has been used widely for clinical applications. Pharmacokinetic modeling of DCE-MRI data that extracts quantitative contrast reagent/tissue-specific model parameters is the most investigated method. One of the primary challenges in pharmacokinetic analysis of DCE-MRI data is accurate and reliable measurement of the arterial input function (AIF), which is the driving force behind all pharmacokinetics. Because of effects such as inflow and partial volume averaging, AIF measured from individual arteries sometimes require amplitude scaling for better representation of the blood contrast reagent (CR) concentration time-courses. Empirical approaches like blinded AIF estimation or reference tissue AIF derivation …