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Treating Breast Cancer With Light: The Creation Of Two Photodynamic Therapy Agents, Victoria Lackey
Treating Breast Cancer With Light: The Creation Of Two Photodynamic Therapy Agents, Victoria Lackey
Honors Theses
Photodynamic therapy (PDT) is a treatment for a wide display of diseases, including cancer, that has become gradually widespread. The procedure requires the usage of photosynthesizing agents, which are activated in the presence of light. One quite successful photodynamic therapy agent is an aromatic structure made up of four pyrrole rings called a porphyrin. This research focused on producing the water-soluble porphyrins, H2TPP-3-PEG-OH and H2TPP-PiperMe-OH, through the attachment of the starting porphyrin, H2TPPC, with 3-polyethyleneglycol and 3-piperidinemethanol, respectively. The novel, water-soluble agent was purified and characterized by infrared spectroscopy (IR), nuclear magnetic resonance spectroscopy (NMR), and UV-vis spectroscopy. Purity was …
Project Emerald: Designing A Language To Be Fun, Addison Bostian
Project Emerald: Designing A Language To Be Fun, Addison Bostian
Honors Theses
I designed the language described here to be, first and foremost, fun. I wanted it to be a programmer's go-to language, the language that you pick up for personal projects or utilities. I felt the way to make this happen was to make it fun to write in. In order to accomplish this, the language derives from several existing languages, taking what I believed were the best parts of each of them. Combining principles from multiple languages sounds like a good idea, I quickly ran into problems that would make developing a compiler extremely difficult, if not impossible. Because of …
Assessing Specificity Of Indazole Derivatives As Inhibitors To Cyp2e1, Hannah Hart
Assessing Specificity Of Indazole Derivatives As Inhibitors To Cyp2e1, Hannah Hart
Honors Theses
Metabolism of drugs in the human body can yield both desirable and undesirable results. Some of these side-effects are due to drug-drug interactions, drug-diet interactions, or lack of drug specificity. The enzymes that drugs attack are structurally selective and complex; therefore, many drugs are very general in structure and could possibly react with a variety of enzymes. Indazole has been used as a backbone for several drugs as it has the general structure that may react with most P450s. To determine a derivative, or a group of derivatives, of indazole that may be reactive only with cytochrome P450 2El (CYP2El), …