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Full-Text Articles in Physical Sciences and Mathematics
Data Assimilation For Conductance-Based Neuronal Models, Matthew Moye
Data Assimilation For Conductance-Based Neuronal Models, Matthew Moye
Dissertations
This dissertation illustrates the use of data assimilation algorithms to estimate unobserved variables and unknown parameters of conductance-based neuronal models. Modern data assimilation (DA) techniques are widely used in climate science and weather prediction, but have only recently begun to be applied in neuroscience. The two main classes of DA techniques are sequential methods and variational methods. Throughout this work, twin experiments, where the data is synthetically generated from output of the model, are used to validate use of these techniques for conductance-based models observing only the voltage trace. In Chapter 1, these techniques are described in detail and the …
Temporal Synchronization Of Ca1 Pyramidal Cells By High-Frequency, Depressing Inhibition, In The Presence Of Intracellular Noise, Stephen A. Kunec
Temporal Synchronization Of Ca1 Pyramidal Cells By High-Frequency, Depressing Inhibition, In The Presence Of Intracellular Noise, Stephen A. Kunec
Dissertations
The Sharp Wave-associated Ripple is a high-frequency, extracellular recording observed in the rat hippocampus during periods of immobility. During the ripple, pyramidal cells synchronize over a short period of time despite the fact that these cells have sparse recurrent connections. Additionally, the timing of synchronized pyramidal cell spiking may be critical for encoding information that is passed on to post-hippocampal targets. Both the synchronization and precision of pyramidal cells is believed to be coordinated by inhibition provided by a vast array of interneurons. This dissertation proposes a minimal model consisting of a single interneuron which synapses onto a network of …