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Full-Text Articles in Physical Sciences and Mathematics
Ph Dependent Antibiotic Resistance Of An Alkaliphilic, Halotolerant Bacterium Isolated From Soap Lake, Washington, Tiffany Charlynn Edwards
Ph Dependent Antibiotic Resistance Of An Alkaliphilic, Halotolerant Bacterium Isolated From Soap Lake, Washington, Tiffany Charlynn Edwards
Masters Theses
"Soap Lake, located in Washington State, is a meromictic, soda lake. Many bacterial isolates retrieved from Soap Lake have been noted to possess resistance to multiple antibiotics. A likely explanation for the wide range of antibacterial resistance exhibited by these strains is due to the impact of high alkalinity on the antibiotics themselves and not due to the presence of antibiotic resistance genes. The aim of our study was to determine if select antibiotics are effective against Halomonas eurialkalitoleranis, a bacterium capable of growth over a wide range of neutral to alkaline pH values, to investigate the influence of alkalinity …
Evaluation Of The Macrocyclic Glycopeptide A-40,926 As A High-Performance Liquid Chromatographic Chiral Selector And Comparison With Teicoplanin Chiral Stationary Phase, Alain Berthod, Timothy Yu, John P. Kullman, Daniel W. Armstrong, Francesco Gasparrini, Ilaria D'Acquarica, Domenico Misiti, Angelo Carotti
Evaluation Of The Macrocyclic Glycopeptide A-40,926 As A High-Performance Liquid Chromatographic Chiral Selector And Comparison With Teicoplanin Chiral Stationary Phase, Alain Berthod, Timothy Yu, John P. Kullman, Daniel W. Armstrong, Francesco Gasparrini, Ilaria D'Acquarica, Domenico Misiti, Angelo Carotti
Chemistry Faculty Research & Creative Works
A new macrocyclic antibiotic of the vancomycin family, referred to by its industrial designation as A-40,926, was bonded to 5 μm silica particles and utilized as a chiral stationary phase (CSP). Since A-40,926 is structurally related to teicoplanin, the A-40,926 CSP was compared to a commercially available teicoplanin CSP. A set of 28 chiral compounds, including amino-acids and related compounds, compounds with a ring containing the stereogenic centre, compounds bearing aromatic structures near their stereogenic centres and alcohols, was tested for enantioseparation on the two CSPs. The results are compared and discussed in terms of enantioselective Gibbs energy difference. The …