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Full-Text Articles in Physical Sciences and Mathematics

Joint Probability Analysis Of Extreme Precipitation And Water Level For Chicago, Illinois, Anna Li Holey Jan 2023

Joint Probability Analysis Of Extreme Precipitation And Water Level For Chicago, Illinois, Anna Li Holey

Dissertations, Master's Theses and Master's Reports

A compound flooding event occurs when there is a combination of two or more extreme factors that happen simultaneously or in quick succession and can lead to flooding. In the Great Lakes region, it is common for a compound flooding event to occur with a high lake water level and heavy rainfall. With the potential of increasing water levels and an increase in precipitation under climate change, the Great Lakes coastal regions could be at risk for more frequent and severe flooding. The City of Chicago which is located on Lake Michigan has a high population and dense infrastructure and …


On The Gaussian-Core Vortex Lattice Model For The Analysis Of Wind Farm Flow Dynamics, Apurva Baruah Jan 2023

On The Gaussian-Core Vortex Lattice Model For The Analysis Of Wind Farm Flow Dynamics, Apurva Baruah

Dissertations, Master's Theses and Master's Reports

Wind power science has seen tremendous development and growth over the last 40 years. Advancements in design, manufacturing, installation, and operation of wind turbines have enabled the commercial deployment of wind power generation systems. These have been due, in a large part, to the expertise in the simulation and modeling of individual wind turbines. The new generation of wind energy systems calls for a need to accurately predict and model the entire wind farm, and not just individual turbines. The commercial deployment of these wind farms depends on model's ability to accurately capture the different physics involved, each at its …


Invasive Buckthorn Mapping: A Uav-Based Approach Utilizing Machine Learning, Gis, And Remote Sensing Techniques In The Upper Peninsula Of Michigan, Vikranth Madeppa Jan 2023

Invasive Buckthorn Mapping: A Uav-Based Approach Utilizing Machine Learning, Gis, And Remote Sensing Techniques In The Upper Peninsula Of Michigan, Vikranth Madeppa

Dissertations, Master's Theses and Master's Reports

An Invasive species is a species that is alien or non-native to the ecosystem which causes harm to economic, environmental, or human health (E.O. 13112 of Feb 3, 1999). Invasive species have posed a serious threat to ecosystems across the globe. These invasive species have impacts on the biodiversity and productivity of invaded forests. Remotely sensed data is a valuable resource for understanding and addressing issues related to invasive species. This study presents a novel approach for mapping the distribution of two invasive plant species, Common and Glossy Buckthorn, using unmanned aerial vehicles (UAVs), machine learning algorithms, geographic information systems …


Structural Analysis And Interpretation Of Deformation Along The Keweenaw Fault System From Lake Linden To Mohawk, Michigan, Nolan G. Gamet Jan 2023

Structural Analysis And Interpretation Of Deformation Along The Keweenaw Fault System From Lake Linden To Mohawk, Michigan, Nolan G. Gamet

Dissertations, Master's Theses and Master's Reports

The Keweenaw fault is likely the most significant and most studied fault associated with the Midcontinent Rift System. The fault roughly bisects the Keweenaw Peninsula and places Portage Lake Volcanics (~1.1 Ga) over much younger Jacobsville Sandstone (~1.0 Ga). Published bedrock geology maps with cross sections from the 1950s show the fault as a single continuous trace that is locally associated with smaller cross faults and splays. The accompanying cross-sections show hanging-wall volcanic strata having a well-defined, listric geometry with dip decreasing away from the fault to the northwest.

This M.S. thesis presents a structural analysis and interpretation of the …


Uhplc/Ft-Ms Non-Targeted Screening Approach For Biomass Burning Organic Aerosol And Liquid Smoke As Biomass Burning Organic Aerosol Surrogate, D.M.R. Thusitha Dinusha Kumarihami Divisekara Jan 2023

Uhplc/Ft-Ms Non-Targeted Screening Approach For Biomass Burning Organic Aerosol And Liquid Smoke As Biomass Burning Organic Aerosol Surrogate, D.M.R. Thusitha Dinusha Kumarihami Divisekara

Dissertations, Master's Theses and Master's Reports

Biomass combustion contributes a large amount of aerosol particles to the atmosphere impacting the climate system and human health. Identifying the molecular composition of biomass burning organic aerosol (BBOA) is challenging because of its complex nature. Liquid chromatography mass spectrometric non-targeted screening (NTS) methods provide a comprehensive analysis. However, the instrumentation and data analysis are challenging due to the extreme complexity of environmental samples. In the first part of this study, we implemented a new LC/FT-MS data processing approach by combining existing open-source data processing tools, MZmine2.53 and MFAssignR. The method's validity was checked using the standard polyacrylic acid (PAA) …


Molecular Dynamics Modeling Of Polymers For Aerospace Composites, Swapnil Sambhaji Bamane Jan 2023

Molecular Dynamics Modeling Of Polymers For Aerospace Composites, Swapnil Sambhaji Bamane

Dissertations, Master's Theses and Master's Reports

Polymer matrix composite materials are widely used as structural materials in aerospace and aeronautical vehicles. Resin/reinforcement wetting and the effect of polymerization on the thermo-mechanical properties of the resin are key parameters in the manufacturing of aerospace composite materials. Determining the contact angle between combinations of liquid resin and reinforcement surfaces is a common method for quantifying wettability. It is challenging to determine contact angle values experimentally of high-performance resins on CNT materials such as CNT, graphene, bundles or yarns, and BNNT surfaces. It is also experimentally difficult to determine the effect of polymerization reaction on material properties of a …


Predicting The Reactivities And Reaction Mechanisms Of Photochemically Produced Reactive Intermediates, Benjamin Barrios Cerda Jan 2023

Predicting The Reactivities And Reaction Mechanisms Of Photochemically Produced Reactive Intermediates, Benjamin Barrios Cerda

Dissertations, Master's Theses and Master's Reports

Photochemically produced reactive intermediates (PPRIs) such as the hydroxyl radical, carbonate radical (CO3•-) singlet oxygen (1O2) and triplet state of chromophoric dissolved organic matter (3CDOM*) are formed in sunlit natural waters upon photoexcitation of chromophoric dissolved organic matter (CDOM). PPRIs react with the organic compounds involved in key environmental processes, resulting in transformation products of smaller molecular weight than their parent compounds. Photochemical transformation of these key water constituents due to their reactions with PPRIs may pose potential effects on human and aquatic ecosystems. Consequently, there is a need …


Neuromorphic Computing Applications In Robotics, Noah Zins Jan 2023

Neuromorphic Computing Applications In Robotics, Noah Zins

Dissertations, Master's Theses and Master's Reports

Deep learning achieves remarkable success through training using massively labeled datasets. However, the high demands on the datasets impede the feasibility of deep learning in edge computing scenarios and suffer from the data scarcity issue. Rather than relying on labeled data, animals learn by interacting with their surroundings and memorizing the relationships between events and objects. This learning paradigm is referred to as associative learning. The successful implementation of associative learning imitates self-learning schemes analogous to animals which resolve the challenges of deep learning. Current state-of-the-art implementations of associative memory are limited to simulations with small-scale and offline paradigms. Thus, …


Novel Approaches To Compute Manifold Operators With The Radial Basis Functions Method, Jacob James Blazejewski Jan 2023

Novel Approaches To Compute Manifold Operators With The Radial Basis Functions Method, Jacob James Blazejewski

Dissertations, Master's Theses and Master's Reports

The bulk of this dissertation is mainly composed of four chapters, which are organized as follows: Chapter 1 provides an introduction to the Radial Basis Functions (RBF) method by briefly outlining its historical developments and reviewing the RBF interpolation and the RBF-Finite Difference (FD) methodologies, and their advantages/disadvantages. Chapter 2 describes the Orthogonal Gradients (OGr) method and the Fast OGr method and how these can be used to compute differential operators restricted to hypersurfaces and space curves ($\Gamma$) embedded in R3. We will highlight a challenge of pairing Fast OGr with RBF-FD on nearly flat local clusters and how to …


Additive P-Value Combination Test, Xing Ling Jan 2023

Additive P-Value Combination Test, Xing Ling

Dissertations, Master's Theses and Master's Reports

This dissertation includes four Chapters. A brief description of each chapter is organized as follows.

In Chapter 1, some developments on multiple hypotheses tests are introduced. Some preliminaries about the definition and the assumption are included.

In Chapter 2, a Stable Combination Test is proposed to combine $p$-values from multiple hypotheses tests. We show the proposed method controls the family-wise error rate at the target level and maintains asymptotically optimal power even when the elementary p-values from the individual hypotheses are dependent.

In Chapter 3, a deeper dig into the additive p-value combination test is performed. A common idea behind …


Chemical Decomposition Of Flexible Polyurethane Foam To Generate A Media For Microbial Upcycling, Kaushik Baruah Jan 2023

Chemical Decomposition Of Flexible Polyurethane Foam To Generate A Media For Microbial Upcycling, Kaushik Baruah

Dissertations, Master's Theses and Master's Reports

Polyurethane waste is becoming a global concern as a large amount is being disposed of in landfills every year, and only a fraction is being recycled. Several polyurethane recycling techniques exist, of which ammonolysis and base-catalyzed hydrolysis is the least explored. Flexible polyurethane foam (FPUF) decomposition can generate amines that can act as a carbon source for the growth of microbial consortia. This study aims to generate a novel media capable of microbial upcycling via ammonolysis and base-catalyzed hydrolysis of flexible polyurethane foams (FPUFs) using ammonium hydroxide and subsequently determine the reaction conditions for maximum solubilization of polyurethane foam in …


Structural Analysis And Slip Kinematics Of The Keweenaw Fault System Between Bête Grise Bay And Gratiot Lake, Keweenaw County, Michigan, Daniel J. Lizzadro-Mcpherson Jan 2023

Structural Analysis And Slip Kinematics Of The Keweenaw Fault System Between Bête Grise Bay And Gratiot Lake, Keweenaw County, Michigan, Daniel J. Lizzadro-Mcpherson

Dissertations, Master's Theses and Master's Reports

The Keweenaw fault is perhaps the most significant geologic structure on the Keweenaw Peninsula, with an estimated 7-11 km of reverse slip juxtaposing volcanic strata of the ~1.1 Ga Portage Lake Volcanics above ~1.0 Ga Jacobsville Sandstone. The fault has been interpreted as a rift-bounding normal fault later inverted by compressional pulses of the Grenville Orogeny or, more recently, as part of a detached thrust fault system unrelated to an earlier normal fault. The fault is shown on published maps as a single continuous fault trace whose sinuosity implies multiple fault segments and complex slip dynamics. Mapping along Bête Grise …


Age And Chemistry Of Bell Creek Batholith, Elana G. Barth Jan 2023

Age And Chemistry Of Bell Creek Batholith, Elana G. Barth

Dissertations, Master's Theses and Master's Reports

The Southern Complex, located near Marquette, Michigan is in the southernmost portion of the Superior Province. This complex consists of granitoids and granitic gneiss that vary in composition. In twentieth century research, Hoffman (1987) and Tinkham (1997) concluded that the Southern Complex contained two units in which the granitoid was emplaced in the granitic gneiss. Recent research conducted by Petryk (2019) determined that the Southern Complex has a U-Pb zircon age of 2600 Ma. Dalle Fratte (2020) concluded that the granitic gneiss migmatite texture was the result of a felsic magma mixing with several generations of mafic intrusions that were …


Surface Reconstruction In Iron Garnets, Sushree Dash Jan 2023

Surface Reconstruction In Iron Garnets, Sushree Dash

Dissertations, Master's Theses and Master's Reports

This dissertation presents the results of a study investigating the physical mechanisms underlying an unexpectedly large increase in magneto-optic efficiency observed in iron garnet. Such materials are technologically important for telecommunications due to their nonreciprocal optical action. In the past, our group had found evidence of an enhanced Faraday rotation in bismuth-substituted iron garnet films less than 50 nm thick. Subsequent investigation revealed that this enhancement could be traced to surface effects. This is significant because understanding these phenomena could be used to formulate engineering solutions for device miniaturization. In this dissertation, we present the result of a research project …


Finer Details Of Language Modeling: Text Segmentation, Working Within Resource Limits, And Watermarking, Evan Gordon Lucas Jan 2023

Finer Details Of Language Modeling: Text Segmentation, Working Within Resource Limits, And Watermarking, Evan Gordon Lucas

Dissertations, Master's Theses and Master's Reports

Language modeling is a vast sub-field of natural language processing and this work focuses on solving some specific problems within that field. Technically, the work falls into a number of sub-categories within natural language processing; how to segment texts, improving sparse transformer performance for summarization tasks, character level models for dialect determination, watermarking of large language models, and a general method of incorporating minimal human feedback for continual or online learning. Despite touching on many small areas, they all connect as being related to the very general problem of handling sequential data. Language and text can be thought of as …


Types Of Questions Teachers Ask To Engage Students In Making Sense Of A Student Contribution, Nishat B. Alam Jan 2023

Types Of Questions Teachers Ask To Engage Students In Making Sense Of A Student Contribution, Nishat B. Alam

Dissertations, Master's Theses and Master's Reports

In the student-centered classroom, a teacher’s interpretation and response to student mathematical contributions plays an important role to shape and direct students’ opportunities for sense-making. This research used a scenario-based survey questionnaire to examine what types of questions middle and high school mathematics teachers indicate they would ask to engage students in making sense of a high-leverage student mathematical contribution and their reasoning about why particular questions are or are not productive. From the results, it could be concluded that teachers asked more productive questions after seeing a set of possible questions. Their beliefs about the productivity of the questions …


Comprehensive Analysis Of Seismic Signals From Pacaya Volcano Using Deep Learning Event Detection, Jessica L. Devlieg Jan 2023

Comprehensive Analysis Of Seismic Signals From Pacaya Volcano Using Deep Learning Event Detection, Jessica L. Devlieg

Dissertations, Master's Theses and Master's Reports

Pacaya volcano located 30 km SW of Guatemala City, Guatemala, has been erupting intermittently since 1961. Monitoring of seismicity is crucial to understanding current activity levels within Pacaya. Traditional methods of picking these small earthquakes in this noisy environment are imprecise. Pacaya produces many small events that can easily blend in with the background noise. A possible solution for this problem is a machine learning program to pick first arrivals for these earthquakes. We tested a deep learning algorithm (Mousavi et al., 2020) for fast and reliable seismic signal detection within a volcanic system. Data from multiple deployments were used, …


The Impact Of Pre-Experiment Walking On Distance Perception In Vr, Soheil Sepahyar Jan 2023

The Impact Of Pre-Experiment Walking On Distance Perception In Vr, Soheil Sepahyar

Dissertations, Master's Theses and Master's Reports

While individuals can accurately estimate distances in the real world, this ability is often diminished in virtual reality (VR) simulations, hampering performance across training, entertainment, prototyping, and education domains. To assess distance judgments, the direct blind walking method—having participants walk blindfolded to targets—is frequently used. Typically, direct blind walking measurements are performed after an initial practice phase, where people become comfortable with walking while blindfolded. Surprisingly, little research has explored how such pre-experiment walking impacts subsequent VR distance judgments. Our initial investigation revealed increased pre-experiment blind walking reduced distance underestimations, underscoring the importance of detailing these preparatory procedures in research—details …


A Search For Compact Object Dark Matter In The Universe Utilizing Gravitational Millilensing Of Gamma-Ray Bursts, Oindabi Mukherjee Jan 2023

A Search For Compact Object Dark Matter In The Universe Utilizing Gravitational Millilensing Of Gamma-Ray Bursts, Oindabi Mukherjee

Dissertations, Master's Theses and Master's Reports

In this dissertation, I explore the existence of Compact Object (CO) Dark Matter (DM), examining its predicted millilensing impact on the light curves of Gamma-Ray Bursts (GRBs). The hypothesis under investigation is that if CO DM exists, it will act as a gravitational lens, influencing light emanating from GRBs and creating a measurable gravitational echo. The detection of this echo is conditional on several factors, including the spatial alignment of the observer, lens, and source and the mass of the CO DM.

Recent studies have reported the potential detection of millilensing in several GRBs, including GRB 950830, GRB 081122A, GRB …


Deep Learning For Medical Image Segmentation Using Prior Knowledge And Topology, Chen Zhao Jan 2023

Deep Learning For Medical Image Segmentation Using Prior Knowledge And Topology, Chen Zhao

Dissertations, Master's Theses and Master's Reports

Image segmentation refers to the division of a digital image into distinct segments or groups of pixels/voxels. However, most of the existing deep learning approaches lack the utilization of prior knowledge, such as shape information, which could improve segmentation accuracy. In addition, conventional image segmentation frequently falls short in preserving intricate spatial details, motivating the innovation of strategies for multi-scaled feature integration. Furthermore, traditional image segmentation methods primarily concentrate on pixel-level or region-level analysis. However, given the inherent morphological similarities among various image objects, the significance of topology information surpasses that of pixel-level data in the realm of medical image …


Climate Changes In El Salvador: Impacts Of ‘La Canícula’ (Midsummer Drought) On Agricultural Practices And Decision-Making In Rural Communities, Paola M. Rivera González Jan 2023

Climate Changes In El Salvador: Impacts Of ‘La Canícula’ (Midsummer Drought) On Agricultural Practices And Decision-Making In Rural Communities, Paola M. Rivera González

Dissertations, Master's Theses and Master's Reports

The Central American Dry Corridor (CADC), a tropical, dry-forest region, is characterized by distinct rainy and dry seasons, which influence the local agricultural calendar and planting decisions in rural communities. La canícula is a period of decreased precipitation during the rainy season, which occurs during the corn-planting season in El Salvador. La canícula is expected to change in intensity and duration in the next decades, which would impact small-scale farmers and their livelihoods. Climate variability and uncertainty has led to crop loss, water scarcity, and food insecurity in rural communities dependent on subsistence farming. Farmers’ experiences with a changing climate …


Exploring High Performance And Energy Efficient Graph Processing On Gpu, Robert P. Watling Jan 2023

Exploring High Performance And Energy Efficient Graph Processing On Gpu, Robert P. Watling

Dissertations, Master's Theses and Master's Reports

Parallel graph processing is central to analytical computer science applications, and GPUs have proven to be an ideal platform for parallel graph processing. Existing GPU graph processing frameworks present performance improvements but often neglect two issues: the unpredictability of a given input graph and the energy consumption of the graph processing. Our prototype software, EEGraph (Energy Efficiency of Graph processing), is a flexible system consisting of several graph processing algorithms with configurable parameters for vertex update synchronization, vertex activation, and memory management along with a lightweight software-based GPU energy measurement scheme. We observe relationships between different configurations of our software, …


Exploring Different Mediums For Teaching Programming And Cybersecurity In Primary And Secondary Schools, Andrew R. Youngstrom Jan 2023

Exploring Different Mediums For Teaching Programming And Cybersecurity In Primary And Secondary Schools, Andrew R. Youngstrom

Dissertations, Master's Theses and Master's Reports

Cybersecurity and programming are becoming more and more prominent in today’s world. It is beneficial to begin teaching these topics to students at a younger age. Additionally, we see students in primary and secondary schools struggling to maintain focus in class as attention spans shrink. This paper looks at different drone models to see if any of them could be sufficient solutions to be implemented into primary and secondary schools to teach cybersecurity and programming topics to students. Besides teaching capabilities, drones must also be affordable for institutions and simple enough to construct, configure, and operate so that a teacher …


Statistical Methods For Gene Selection And Genetic Association Studies, Xuewei Cao Jan 2023

Statistical Methods For Gene Selection And Genetic Association Studies, Xuewei Cao

Dissertations, Master's Theses and Master's Reports

This dissertation includes five Chapters. A brief description of each chapter is organized as follows.

In Chapter One, we propose a signed bipartite genotype and phenotype network (GPN) by linking phenotypes and genotypes based on the statistical associations. It provides a new insight to investigate the genetic architecture among multiple correlated phenotypes and explore where phenotypes might be related at a higher level of cellular and organismal organization. We show that multiple phenotypes association studies by considering the proposed network are improved by incorporating the genetic information into the phenotype clustering.

In Chapter Two, we first illustrate the proposed GPN …


Study Of Electronic And Magnetic Properties Of Bilayer Graphene Nanoflakes And Bimetallic Chalcogenides Using First-Principles Density Functional Theory And Machine Learning, Dharmendra Pant Jan 2023

Study Of Electronic And Magnetic Properties Of Bilayer Graphene Nanoflakes And Bimetallic Chalcogenides Using First-Principles Density Functional Theory And Machine Learning, Dharmendra Pant

Dissertations, Master's Theses and Master's Reports

Graphene, a one-atom-thick material, has been a wonder material since its discovery because of its superlative electronic, mechanical, and optical properties. When a layer of graphene is rotated over another layer, it exhibits many intriguing behaviors, ranging from superconductivity to the anomalous Hall effect to ferromagnetism at a magic angle of 1°, and hence the twisted bilayer graphene has been the subject of intense research in recent years. The surge in interest in this moiré structure can be attributed to the emergence of electronic flat minibands near the magic angle. Here, we studied the electronic and magnetic properties of twisted …


Multiscale Molecular Modeling Studies Of The Dynamics And Catalytic Mechanisms Of Iron(Ii)- And Zinc(Ii)-Dependent Metalloenzymes, Sodiq O. Waheed Jan 2023

Multiscale Molecular Modeling Studies Of The Dynamics And Catalytic Mechanisms Of Iron(Ii)- And Zinc(Ii)-Dependent Metalloenzymes, Sodiq O. Waheed

Dissertations, Master's Theses and Master's Reports

Enzymes are biological systems that aid in specific biochemical reactions. They lower the reaction barrier, thus speeding up the reaction rate. A detailed knowledge of enzymes will not be achievable without computational modeling as it offers insight into atomistic details and catalytic species, which are crucial to designing enzyme-specific inhibitors and impossible to gain experimentally. This dissertation employs advanced multiscale computational approaches to study the dynamics and reaction mechanisms of non-heme Fe(II) and 2-oxoglutarate (2OG) dependent oxygenases, including AlkB, AlkBH2, TET2, and KDM4E, involved in DNA and histone demethylation. It also focuses on Zn(II) dependent matrix metalloproteinase-1 (MMP-1), which helps …


Information Use And Decision-Making For Evacuation At Fuego Volcano, Guatemala, Beth A. Bartel Jan 2023

Information Use And Decision-Making For Evacuation At Fuego Volcano, Guatemala, Beth A. Bartel

Dissertations, Master's Theses and Master's Reports

For populations living with risk to rapid-onset environmental hazards, an effective early warning system (EWS) may be the most viable short- to mid-term solution for risk reduction. At Fuego volcano, Guatemala, more than 60,000 people distributed between more than 30 small communities live within the identified hazard zones for pyroclastic density currents (PDCS), highly lethal hot avalanches and surges of volcanic gases, rock, and ash. Despite ongoing risk reduction efforts by scientific and civil protection authorities, more than 400 people died during a paroxysmal eruption on 3 June 2018 when PDCs reached populated areas. A high-end resort, La Reunión, evacuated …


Tracing The Most Powerful Galactic Cosmic-Ray Accelerators With The Hawc Observatory, Dezhi Huang Jan 2023

Tracing The Most Powerful Galactic Cosmic-Ray Accelerators With The Hawc Observatory, Dezhi Huang

Dissertations, Master's Theses and Master's Reports

Since Victor Hess's groundbreaking detection of cosmic rays in the Earth's atmosphere in 1912, the origins of these charged particles have remained an enduring mystery. Recent studies suggest that these cosmic rays are accelerated beyond Peta electronvolts by powerful astrophysical sources within our own galaxy. While the cosmic rays themselves are being deflected in all directions by magnetic fields, the gamma rays produced by them, being electrically neutral, travel to the observer in a straight line. They carry crucial information, allowing us to trace cosmic-ray accelerators within our galaxy. The High Altitude Water Chrenkov (HAWC) Observatory, located on the slopes …


Integrating Lidar, Aeromagnetic, And Geological Field Data To Identify Structural-Lithologic Elements Within The Archean Carney Lake Gneiss Complex, Ian M. Gannon Jan 2023

Integrating Lidar, Aeromagnetic, And Geological Field Data To Identify Structural-Lithologic Elements Within The Archean Carney Lake Gneiss Complex, Ian M. Gannon

Dissertations, Master's Theses and Master's Reports

The Archean Carney Lake Gneiss Complex (CLGC) is a suite of rocks on the southern margin of the Superior Province and within the Minnesota River Valley subprovince. It is one of many gneissic domes in Michigan, Wisconsin, and Minnesota whose complex geology is poorly understood due to a previous lack of economic interest in gneissic terranes and significant challenges to their investigation. As a consequence, the CLGC and other gneissic domes in the region are represented on geologic maps as undifferentiated masses surrounded by better defined and understood Paleoproterozoic supracrustal rocks and igneous intrusions. Within the last ten years, however, …


Prediction Of Sumoylation Sites In Proteins From Language Model Representations, Evgenii Sidorov Jan 2023

Prediction Of Sumoylation Sites In Proteins From Language Model Representations, Evgenii Sidorov

Dissertations, Master's Theses and Master's Reports

Sumoylation is an essential post-translational modification intimately involved in a diverse range of eukaryotic cellular mechanisms and plays a significant role in DNA repair. Some researchers hypothesize that a high level of SUMOylation events in cancer cells improves cells' chances for survival under stress conditions by regulating tumor-related proteins.

This study belongs to a booming field of harnessing computational power to the domain of life. Prediction of protein structure, its molecular function, and the design of new drugs are just a few examples of the applications within this exciting area of research. By leveraging computational power, researchers can analyze vast …