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Full-Text Articles in Physical Sciences and Mathematics
Serotonin 5-Ht4 Agonist Activity Of A Series Of Meso-Azanoradamantane Benzamides, Daniel Becker, Roger Nosal, Clara I. Villamil, Gary Gullikson
Serotonin 5-Ht4 Agonist Activity Of A Series Of Meso-Azanoradamantane Benzamides, Daniel Becker, Roger Nosal, Clara I. Villamil, Gary Gullikson
Chemistry: Faculty Publications and Other Works
A series of meso-amino(methyl)azanoradamantane benzamides has been prepared and evaluated for 5-HT4agonism activity in the rat tunica muscularis mucosae (TMM) assay. Compound 8i is the most potent 5-HT4agonist in the series, with an EC50 of 217 nM.
Synthetic Strategies For The Construction Of Enantiomeric Azanoradamantanes, Daniel Becker, Roger Nosal, Daniel L. Zabrowski, Daniel Flynn
Synthetic Strategies For The Construction Of Enantiomeric Azanoradamantanes, Daniel Becker, Roger Nosal, Daniel L. Zabrowski, Daniel Flynn
Chemistry: Faculty Publications and Other Works
The amino azanoradamantane hexahydro-2,5b-methano-IH-3aS,3aa,6aa-cyclopenta-[clpyrrole-4a-amine 1and the corresponding enantiomer ent-1 have been prepared along with benzamide derivatives SC-52491and SC-52490, respectively, which are of pharmaceutical interest. The key meso-azabicyclo[3.3.0] intermediate 3 was prepared via three separate routes: a [3+2] cycloaddition route, a radical cyclization/ionic cyclization route, and a reductive Pauson-Khand route.