Physical Sciences and Mathematics Commons^™

Modeling Anatomic Changes For Adaptive Radiotherapy In Locally Advanced Lung Cancer Patient Population, James Alexander Kavanaugh

LSU Doctoral Dissertations

Anatomic changes occurring mid-treatment for patients undergoing radiation therapy for locally advanced lung cancer can degrade the quality of the intended treatment plan. These changes include tumor regression, geometric misalignment, and lung density changes (atelectasis and pleural effusion), and are visible on the daily 3D cone beam CT (CBCT). To maintain the intended treatment quality, adaptive radiotherapy (ART) can be employed to modify the treatment plan to account for these anatomic changes. However, the evaluation on when to adapt is currently completed manually by the treating clinicians, resulting in a subjective and inconsistent application. To address these limitations, a series …

Accurate Tracking Of Position And Dose During Vmat Based On Vmat-Ct, Xiaodong Zhao

LSU Doctoral Dissertations

Purpose: Local tomography reconstruction is achievable with EPID images acquired during VMAT and was named as VMAT-CT. However, it did not gain popularity due to multiple limitations and technical challenges. The goal of this study was to extend VMAT-CT concept, generate complete 3D or 4D CT images and dose, track and adapt VMAT plan based on updated images and dose.

Methods: We considered collimator angle and removed blurred areas in EPID images for VMAT-CT reconstruction to reduce artifacts and improve image quality. VMAT-CT+ images were generated by fusing VMAT-CT and planning CT using rigid or deformable registration. For 4D SBRT …