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Louisiana State University

2016

Synthesis

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Full-Text Articles in Physical Sciences and Mathematics

Visible Light And Electron Transfer Chemistry For O-Glycosylation And Remote Hydroxylation, Mark Louis Spell Jan 2016

Visible Light And Electron Transfer Chemistry For O-Glycosylation And Remote Hydroxylation, Mark Louis Spell

LSU Doctoral Dissertations

This dissertation focuses on the synthesis of dauer pheromone analogs for biological evaluation, the development of visible light promoted O-glycosylation methods and the development of an Ir(ppy)3 catalyzed C-H hydroxylation method. Chapter 1 describes the synthesis of dauer pheromone analogs. C.elegans is a small nematode that enters a dauer stage when encountering unfavorable environmental conditions. The dauer stage is initiated by the nematodes chemosensation of the dauer pheromone caused by the down regulation biochemical pathways TGF-â and IGF-1. These biochemical pathways are also seen in Homo Sapiens and play a role in a number of biological processes. Understanding how these …

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Synthetic Approach Towards P3eht-B-Pss Conjugated And Ionic Block Copolymer, Zhaoyuan Liu Jan 2016

Synthetic Approach Towards P3eht-B-Pss Conjugated And Ionic Block Copolymer, Zhaoyuan Liu

LSU Master's Theses

This work is focused on the design, synthesis and characterization of block copolymers (BCPs) containing both conjugated and polyelectrolyte blocks. This type of rod-coil BCP is considered to have microphase separation which is different compared to coil-coil BCPs. The conjugated block used for studies is regioregular poly(3-alkylthiophene) (P3AT), which can be synthesized by Grignard metathesis (GRIM) polymerization. The polyelectrolyte block used is polystyrene sulfonate with well-defined structure, which can be synthesized by atom transfer radical polymerization (ATRP). Chapter II is focused on evaluation of synthetic routes for P3EHT-b-PSS, including using bifunctional initiator to synthesize both blocks, and separately synthesizing end-functionalized …

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