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Full-Text Articles in Physical Sciences and Mathematics
Nanoparticles For Mercury Abatement, Sunil Krishna Thanikanti
Nanoparticles For Mercury Abatement, Sunil Krishna Thanikanti
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Mercury is considered to be a global contaminant. It does not break down in the environment and can build up in living organisms. Mercury can be carried long distances on wind currents, staying in the atmosphere for long periods of time, when in its vapor form. High mercury exposure results in permanent nervous system and kidney damage. Mercury exists in three different chemical forms: elemental, inorganic, and organic. The routes of exposure can be inhalation, ingestion, or skin contact. Vapor from liquid elemental mercury and methyl mercury are more easily absorbed than inorganic mercury salts and can, therefore, cause more …
Encapsulated Antibiotic Nanoparticles For Cranial Transplantation, Adusumilli Naga Anusha
Encapsulated Antibiotic Nanoparticles For Cranial Transplantation, Adusumilli Naga Anusha
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The purpose of this research is to develop a unique nanoparticulate system that is capable of delivering antibiotics in a locally applied and extended-release manner for patients receiving cranial replacement implants and bone grafting. This study involves three major components: first, encapsulate both hydrophobic antibiotics (chloramphenicol and rifampicine) and hydrophilic antibiotics (vancomycine and acyclovir) into nanoparticles. Second, incorporate antibiotic nanoparticles in a polymeric coating material (nitrocellulose plus 7.0% (w/v) polyvinylpyrrolidone) with a volatile carrier solvent (ethyl acetate or ethanol). Third, directly apply the resulting product from component 1 and 2 to polymethyl methacrylate (PMMA) cranial implants and hydroxylapatite (HA) bone …
Nanoencapsulated Drug-Carrying System For Photodynamic Antimicrobial Chemotherapy (Pact), Gopala Krishna Murthy Kalapala
Nanoencapsulated Drug-Carrying System For Photodynamic Antimicrobial Chemotherapy (Pact), Gopala Krishna Murthy Kalapala
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The purpose of this study is to develop nanoparticulate drug-carrying systems that are capable of directly delivering photodynamic antimicrobial agents to treat patients with chronic wounds. Chronic wounds are considered as a pandemic health problem. Approximately 1% to 2% of the population in developing countries has experienced a chronic wound during their lifetime. In the United State States, according to the American Academy of Dermatology, the expense of treating chronic wounds constitutes over half of the total cost for all skin diseases, which exceeds $10 billion annually. For the last decade extensive basic science and clinical research in chronic wounds …
Detection Of Folate Binding Protein, Anwer Unnisa
Detection Of Folate Binding Protein, Anwer Unnisa
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Cancer is the second leading cause of death despite the anti cancer developments including hormone therapy, radiotherapy, chemotherapy. Chemotherapy includes use of potent drugs such as camptothecin, paclitaxel and mitomycin. These drugs have an effect which is dose responsive, where the drug exposure and cell kill are proportional. This chemotherapy is high dose and has less selectivity for cancer cells and has more toxic effect to normal cells. Such kind of non specific treatment to tumor is causing hurdles in the treatment of cancer by chemotherapy. To overcome this current limitation to chemotherapy, the anti cancer drug with high specificity …
Synthesis And Characterization Of Nanoparticulated Rifampicin, Lakshmi Sai Priyanka Guttikonda
Synthesis And Characterization Of Nanoparticulated Rifampicin, Lakshmi Sai Priyanka Guttikonda
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Rifampicin is a naturally made, non-peptide antibiotic. It is bactericidal, killing by disabling the protein expression system universally conserved by all bacteria. Specifically, it inhibits the RNA polymerase protein, which is responsible for binding to a strand of DNA as a template and using it to construct a strand of mRNA. The reason rifampicin works so well is that it is a rigid molecule, and sits tightly in the pocket where it binds, allowing the bonds to be very strong. However, this also means if an amino acid with the edge of the channel with a small side chain is …