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Physical Sciences and Mathematics Commons™
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Full-Text Articles in Physical Sciences and Mathematics
Guest Editors' Introduction, Jianer Chen, Ion Măndoiu, Raj Sunderraman, Jianxin Wang, Alexander Zelikovskiy
Guest Editors' Introduction, Jianer Chen, Ion Măndoiu, Raj Sunderraman, Jianxin Wang, Alexander Zelikovskiy
Computer Science Faculty Publications
This Supplement includes a selection of papers presented at the 7th International Symposium on Bioinformatics Research and Application (ISBRA), which was held on May 27-29, 2011 at Central South University in Changsha, China. The technical program of the symposium included 36 extended abstracts presented orally and published in volume 6674 of Springer Verlag’s Lecture Notes in Bioinformatics series. Additionally, the program included 38 short abstracts presented either orally or as posters. Authors of both extended and short abstracts presented at the symposium were invited to submit full versions of their work to this Supplement. Following a rigorous review process, 19 …
Efficient Error Correction For Next-Generation Sequencing Of Viral Amplicons, Pavel Skums, Zoya Dimitrova, David S. Campo, Gilberto Vaughan, Livia Rossi, Joseph C. Forbi, Jonny Yokosawa, Alexander Zelikovskiy, Yury Khudyakov
Efficient Error Correction For Next-Generation Sequencing Of Viral Amplicons, Pavel Skums, Zoya Dimitrova, David S. Campo, Gilberto Vaughan, Livia Rossi, Joseph C. Forbi, Jonny Yokosawa, Alexander Zelikovskiy, Yury Khudyakov
Computer Science Faculty Publications
Background: Next-generation sequencing allows the analysis of an unprecedented number of viral sequence variants from infected patients, presenting a novel opportunity for understanding virus evolution, drug resistance and immune escape. However, sequencing in bulk is error prone. Thus, the generated data require error identification and correction. Most error-correction methods to date are not optimized for amplicon analysis and assume that the error rate is randomly distributed. Recent quality assessment of amplicon sequences obtained using 454-sequencing showed that the error rate is strongly linked to the presence and size of homopolymers, position in the sequence and length of the amplicon. All …