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Full-Text Articles in Physical Sciences and Mathematics
Time-Dependent Regulation Of Apoptosis By Aen And Bax In Response To 2-Aminoanthracene Dietary Consumption, Worlanyo E. Gato, Dale B. Hales, Stacey R. Mcgee, Jay C. Means
Time-Dependent Regulation Of Apoptosis By Aen And Bax In Response To 2-Aminoanthracene Dietary Consumption, Worlanyo E. Gato, Dale B. Hales, Stacey R. Mcgee, Jay C. Means
Department of Chemistry and Biochemistry Faculty Publications
Background/Objective: The modulation of the toxic effects of 2-aminoanthracene (2AA) on the liver by apoptosis was investigated. Fisher-344 (F344) rats were exposed to various concentrations of 2AA for 14 and 28 days. The arylamine 2AA is an aromatic hydrocarbon employed in manufacturing chemicals, dyes, inks, and it is also a curing agent in epoxy resins and polyurethanes. 2AA has been detected in tobacco smoke and cooked foods.
Methods: Analysis of total messenger ribonucleic acid (mRNA) extracts from liver for apoptosis-related gene expression changes in apoptosis enhancing nuclease (AEN), Bcl2-associated X protein (BAX), CASP3, Jun proto-oncogene (JUN), murine double minute-2 p53 …