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Full-Text Articles in Physical Sciences and Mathematics
Synthesizing Topological Structures Containing Rna, Di Liu, Yaming Shao, Gang Chen, Yuk-Ching Tse-Dinh, Joseph A. Piccirilli, Yossi Weizmann
Synthesizing Topological Structures Containing Rna, Di Liu, Yaming Shao, Gang Chen, Yuk-Ching Tse-Dinh, Joseph A. Piccirilli, Yossi Weizmann
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Though knotting and entanglement have been observed in DNA and proteins, their existence in RNA remains an enigma. Synthetic RNA topological structures are significant for understanding the physical and biological properties pertaining to RNA topology, and these properties in turn could facilitate identifying naturally occurring topologically nontrivial RNA molecules. Here we show that topological structures containing single-stranded RNA (ssRNA) free of strong base pairing interactions can be created either by configuring RNA?DNA hybrid four-way junctions or by template-directed synthesis with a single-stranded DNA (ssDNA) topological structure. By using a constructed ssRNA knot as a highly sensitive topological probe, we find …
Detection Of Lipid-Induced Structural Changes Of The Marburg Virus Matrix Protein Vp40 Using Hydrogen/Deuterium Exchange-Mass Spectrometry, Kaveesha J. Wijesinghe, Sarah Urata, Nisha Bhattarai, Edgar E. Kooijman, Bernard S. Gerstman, Prem P. Chapagain, Sheng Li, Robert V. Stahelin
Detection Of Lipid-Induced Structural Changes Of The Marburg Virus Matrix Protein Vp40 Using Hydrogen/Deuterium Exchange-Mass Spectrometry, Kaveesha J. Wijesinghe, Sarah Urata, Nisha Bhattarai, Edgar E. Kooijman, Bernard S. Gerstman, Prem P. Chapagain, Sheng Li, Robert V. Stahelin
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Marburg virus (MARV) is a lipid-enveloped virus from the Filoviridae family containing a negative sense RNA genome. One of the seven MARV genes encodes the matrix protein VP40, which forms a matrix layer beneath the plasma membrane inner leaflet to facilitate budding from the host cell. MARV VP40 (mVP40) has been shown to be a dimeric peripheral protein with a broad and flat basic surface that can associate with anionic phospholipids such as phosphatidylserine. Although a number of mVP40 cationic residues have been shown to facilitate binding to membranes containing anionic lipids, much less is known on how mVP40 assembles …
Crystal Structure Of Μ6-Chlorido-NonaKis(Μ-4-ChloroPyrazolato)Bis-Μ3-Methoxo-HexaCopper(Ii), Kaige Shi, Logesh Mathivathanan, Raphael G. Raptis
Crystal Structure Of Μ6-Chlorido-NonaKis(Μ-4-ChloroPyrazolato)Bis-Μ3-Methoxo-HexaCopper(Ii), Kaige Shi, Logesh Mathivathanan, Raphael G. Raptis
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The hexa_nuclear copper pyrazolato complex has a trigonal prismatic shape and contains an encapsulated chloride ligand.