Physical Sciences and Mathematics Commons^™

Synthesis Of The Bicyclic Core Of Pyrrolizidine Alkaloids, Fatmagul Tuluoglu

Master's Theses and Doctoral Dissertations

Pyrrolizidine alkaloids are a large class of natural products whose members exhibit a variety of biological properties including potential applications toward the treatment of cancer, diabetes, and viral infections such as HIV. In addition, some of these compounds exhibit insect antifeedant activity, and so have potential applications in the agricultural industry for the protection of crops.

For these reasons, we were interested in developing a method to form the bicyclic alkaloid core that could be functionalized to generate many pyrrolizidine alkaloids. Specifically, our goal was to synthesize the pyrrolizidine B-ring by a novel McMurry cyclization strategy (Scheme 1). The synthesis …

Controlling The Diastereoselectivity In The Microwave-Assisted Aza-Cope Rearrangement--Mannich Cyclization, Wesley A. Turley

Master's Theses and Doctoral Dissertations

No abstract provided.

Synthesis Of An Aza-Cope Rearrangement - Mannich Cyclization Precursor From L-Proline, Patricia T. Sinawe

Senior Honors Theses and Projects

No abstract provided.