Open Access. Powered by Scholars. Published by Universities.®
Physical Sciences and Mathematics Commons™
Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 3 of 3
Full-Text Articles in Physical Sciences and Mathematics
An Improved Synthesis Of The Hdac Inhibitor Trichostatin A, Joseph Colombo
An Improved Synthesis Of The Hdac Inhibitor Trichostatin A, Joseph Colombo
Master's Theses and Doctoral Dissertations
Histone deacetylase inhibitors (HDIs) have found a wide variety of medicinal uses and are most noted for their specific apoptotic action towards cancer cells. Several hydroxamate HDIs have since been moved on to phase 1 and 2 clinical drug trials, with one having already been approved for treatment of advanced cutaneous T-cell lymphoma. Trichostatin A is one of the most potent known naturally-occurring inhibitors of histone deacetylase. Unfortunately for researchers, the syntheses that have been reported are both long and difficult, which leads to a low overall yield and therefore to a prohibitively expensive product, limiting its medicinal potential. This …
Effect Of Counter Ion Concentration Added With Mixture Of Water And Ethylene Glycol On Krafft Temperature Of Sodium Dodecyl Sulfate, Sateesh Krishna Chand Chundru
Effect Of Counter Ion Concentration Added With Mixture Of Water And Ethylene Glycol On Krafft Temperature Of Sodium Dodecyl Sulfate, Sateesh Krishna Chand Chundru
Master's Theses and Doctoral Dissertations
Surfactants are amphiphilic organic compounds having both hydrophobic and hydrophilic groups. Surfactants in solution form aggregates known as micelles. The minimum temperature at which surfactants forms micelles is known as Krafft temperature. The Krafft temperature of sodium dodecyl sulfate (SDS) was measured at various counter ion concentrations in two solvent systems, water and 10% ethylene glycol. The Krafft temperature of sodium dodecyl sulfate increased in both water and 10% ethylene glycol with increasing counter ion concentration. The Krafft temperature of sodium dodecyl sulfate in 10% ethylene glycol was higher than the Krafft temperature of sodium dodecyl sulfate in water, at …
The Effect Of The Reducing Agent Triphenylphosphine On Arachidonic Acid Metabolism By Prostaglandin H2 Synthase, Lalini Ailaboina
The Effect Of The Reducing Agent Triphenylphosphine On Arachidonic Acid Metabolism By Prostaglandin H2 Synthase, Lalini Ailaboina
Master's Theses and Doctoral Dissertations
Prostaglandin H2 synthase (PGHS) catalyzes the conversion of arachidonic acid to prostaglandin endoperoxide (PGH2), which is a precursor to a variety of prostaglandins that function as hormones. Gas chromatography combined with mass spectrometry is employed to look for the novel products produced by reaction of triphenylphosphine with arachidonic acid prior to and during the PGHS reaction. Triphenylphosphine (TPP) is known to reduce hydro peroxides to alcohols and is used in the present study to ascertain the extent to which hydroperoxides in arachidonic acid preparations and in PGHS contribute to enzyme activity. Incubation of PGHS with arachidonic acid that was treated …